Models

Conditional Knockouts

In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.

Mice
Strain Name:C57BL/6Smoc-Fzr1em1(flox)Smoc
Strain State:Developing | Cat. NO.:TBD
Mice
Strain Name:C57BL/6JSmo-G0s2em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-231799
Mice
Strain Name:C57BL/6Smoc-G2e3em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-251868
Mice
Strain Name:C57BL/6JSmo-G3bp1em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-233964
Mice
Strain Name:C57BL/6JSmo-G3bp2em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-241897
Mice
Strain Name:C57BL/6JSmo-G6pcem1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-200053
Disease Connection:glycogen storage disease I
Mice
Strain Name:C57BL/6Smoc-G6pc2em1(flox)Smoc
Strain State:Repository Live | Cat. NO.:NM-CKO-254121
Mice
Strain Name:C57BL/6JSmo-G6pc3em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-2106534
Mice
Strain Name:C57BL/6Smoc-G6pd2em1(flox)Smoc
Strain State:Developing | Cat. NO.:TBD
Mice
Strain Name:C57BL/6Smoc-Gaaem1(flox)Smoc
Strain State:Developing | Cat. NO.:TBD
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