In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.
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Strain Name：C57BL/6Smoc-Brca2tm1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200014
Disease Connection：breast cancer, prostate cancer, medulloblastoma, pancreatic carcinoma
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Strain Name：C57BL/6Smoc-Brcc3em(flox)/Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-230305
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Strain Name：C57BL/6Smoc-Brd1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-232406
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Strain Name：C57BL/6Smoc-Brd4em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-232281
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Strain Name：B6;129S-Brd7tm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00034
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Strain Name：C57BL/6Smoc-Brd9em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-210043
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