In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.
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Strain Name：C57BL/6Smoc-Bptfem1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-2102355
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Strain Name：C57BL/6Smoc-Brafem1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200073
Disease Connection：melanoma, thyroid gland papillary carcinoma, skin melanoma, prostate cancer, Langerhans-cell histiocytosis, cardiofaciocutaneous syndrome
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Strain Name：C57BL/6Smoc-Brca1tm1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-18007
Disease Connection：breast cancer, hereditary breast ovarian cancer syndrome
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