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U-GEMMs

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Mice

R26-CreERT2

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-FRT-2xpolyA-CAG-FRT-CreERT2-Rox-WPRE-Rox-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200041

These mice harbor a SA-FRT-2xpolyA-CAG-FRT-CreERT2-Rox-WPRE-Rox-polyA cassette in the Rosa26 locus generated by homologous recombination. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in multiple tissues after tamoxifen treatment.

Mice

Foxp3-IRES-DTRGFP

Strain Name：C57BL/6Smoc-Foxp3em3(IRES-DTREGFP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190046

A IRES-DTREGFP expression cassette was knocked into the Foxp3 gene stop codon site.

Mice

hIFNGR1/hIFNGR2

Strain Name：C57BL/6Smoc-Ifngr1em3(hIFNGR1)Ifngr2tm(hIFNGR2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220003

hIFNGR1(NM-HU-190076) was crossed with hIFNGR2(NM-HU-215010) to generate hIFNGR1/hIFNGR2 mice.

Mice

R26-CAG-LSL-hFGFR2-IRES-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-2xpolyA-CAG-LSL-FGFR2-luciferase-EGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-190007

A SA-2xpolyA-CAG-LSL-FGFR2-IRES-luciferase-2A-EGFP-WPRE-polyA cassette was inserted at the Rosa26 locus. When bred to a strain expressing Cre recombinase under control of various tissue specific promoters, Cre recombination deletes the LSL cassette and allows the expression of the FGFR2 protein.

Mice

Hif1a-Flox

Strain Name：C57BL/6Smoc-Hif1atm1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-190065

These mice carry loxP sites flanking exon 2 of Hif1a gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Hif1a gene.

Mice

Npr3-2A-DreERT2

Strain Name：C57BL/6Smoc-Npr3em1(2A-DreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190015

The 2A-DreERT2 cassette is inserted before 3'UTR region of Npr3 gene.

Mice

R26-CAG-LSL-hFGFR2*S320C-IRES-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-FGFR2(S320C)-IRES-Luciferase-2A-EGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-190079

These mice harbor a CAG-LSL-FGFR2(S320C)-IRES-Luciferase-2A-EGFP cassette in the Rosa26 locus generated by homologous recombination.

Mice

Pd-1-KO

Strain Name：C57BL/6Smoc-Pdcd1em3Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190423

The Pdcd1 knockout mouse model was generated by knocking out the exon2-4 region of the Pdcd1.

Mice

R26-CAG-LSL-hFGFR3-IRES-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-FGFR3-IRES-Luciferase-2A-EGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-190083

These mice harbor a CAG-LSL-FGFR3-IRES-Luciferase-2A-EGFP cassette in the Rosa26 locus generated by homologous recombination.

Mice

Abcb11-KO

Strain Name：C57BL/6Smoc-Abcb11em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18010

Exon5 of Abcb11 gene was deleted to generate Abcb11 knockout mice.

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