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U-GEMMs

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Mice

Slc6a1-KO

Strain Name：B6;129S-Slc6a1tm1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-00002

Slc6a1-KO mice(Stock No.NM-KO-00002）carry a knockout allele derived from the targeted deletion of exon 2-3. While Slc6a1-KO(2) mice (Stock No.NM-KO-210290）carrying the exon 6 deletion. Slc6a1-KO(3) mice(Stock No.NM-KO-210126） carrying the exon 7 deletion.

Mice

hIL23A

Strain Name：C57BL/6Smoc-Il23aem3(hIL23A)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-18030

The endogenous mouse Il23a gene was replaced by humanIL23A gene .

Mice

A2m-Flox

Strain Name：C57BL/6Smoc-A2mem1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of A2m gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of A2m gene.

Mice

hCD3EDG/hCD28

Strain Name：C57BL/6Smoc-Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)Cd28em2(hCD28) /Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220113

hCD3EDG(NM-HU-220120) mice were crossed with hCD28(NM-HU-190011) to generate hCD3EDG/hCD28 mouse

Mice

R26-LSL-hIL15-Flag-IRES-EGFP

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem(CAG-Loxp-Stop-Loxp-Kozak-hIL2 signal peptide-hIL15-Flag-IRES-EGFP-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-220130

CAG-Loxp-Stop-Loxp-Kozak-hIL2 signal peptide-hIL15-Flag-IRES-EGFP-polyA expression cassette was knocked into the the Rosa26 locus

Mice

hTREM2

Strain Name：C57BL/6Smoc-Trem2em4(hTRem2)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000083

The endogenous mouse Trem2 gene was replaced by human TREM2 gene.

Mice

hPD-L1/hCD40

Strain Name：C57BL/6Smoc-Cd274em1(hPD-L1)Cd40em1(hCD40)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18024

hPD-L1(NM-HU-00062) was crossed with hCD40(NM-HU-00076) to generate hPD-L1/hCD40.

Mice

Il18-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il18em1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00032

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il18.

Mice

Emx1-IRES-Cre

Strain Name：C57BL/6Smoc-emx1em1(IRES-Cre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200149

A IRES-Cre expression cassette was knocked into the Emx1 gene stop codon site.

Mice

Il9-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il9em1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00023

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il9.

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