SMOC has developed a set of mouse models expressing humanized immune checkpoints. These models are suitable to assess the efficacy of drugs targeting immune checkpoints in fully immunocompetent mice.
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Strain Name：C57BL/6Smoc-Tlr8tm2(TLR8)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190044
Research Application：Immunotherapy,cancer research,drug screening
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Strain Name：C57BL/6Smoc-Tlr8tm2(TLR8)Pdcd1em1(hPDCD1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200276
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Strain Name：C57BL/6Smoc-Lyz2em3(IRES-DTREGFP)Tlr8tm2(TLR8)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200259
Research Application：tumor research；inmmue therapy；drug screening;myeloid cell-specific DTR mice
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Strain Name：C57BL/6Smoc-Tlr9tm1(hTLR9)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18016
Research Application：drug screening
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Strain Name：C57BL/6Smoc-Tlr9tm1(hTLR9)Tnfrsf4em3(hTNFRSF4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190024
Research Application：Immune-related
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Strain Name：C57BL/6Smoc-Tnfrsf1bem2(hTNFRSF1B)Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220041
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Strain Name：C57BL/6Smoc-Tnfrsf12aem(hTNFRSF12A)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-230046
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Strain Name：C57BL/6Smoc-Trem2em4(hTRem2)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000083
Research Application：Alzheimer's disease research;drug screening
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Strain Name：C57BL/6Smoc-Vsirem1(hVSIR)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00118
Research Application：Immunotherapy,cancer research,drug screening
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Strain Name：C57BL/6Smoc-Vsig4em1(hVSIG4)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210004
Research Application：inmmue therapy；drug screening
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