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Models

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Mice

hIDO1

Strain Name：B6;129S-Ido1tm1(hIDO1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00061
Validation Data：Presence

The endogenous mouse Ido1 gene was replaced by human IDO1 gene.

Mice

hPD-1/hLAG3

Strain Name：C57BL/6JSmo-Pdcd1tm1(hPDCD1)Lag3tm1(hLAG3)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00101

hPD-1(NM-HU-00015) was crossed with hLAG3(NM-HU-00049)to generate hPD-1/hLAG3 mice

Mice

Tie1-2A-Cre

Strain Name：C57BL/6JSmo-Tie1em1(2A-Cre)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18023

A 2A-Cre coexpression cassette is inserted befor the stop codon of mouse Tie1 gene via homologous recombination to establish a tamoxifen inducible Tie1-Cre tool stain. This strain can be used to knockout target gene in Tie1+ cells when crossed with mice which carry loxp sites flanking target gene.

Mice

Alms1-del(c.3802-3812)

Strain Name：C57BL/6JSmo-Alms1em(delc.3802-3812)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-220067

These mice carry a del(c.3802-3812) mutation of Alms1 gene.

Mice

hAPOE4

Strain Name：C57BL/6JSmo-Apoetm2(hAPOE4)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190002
Validation Data：Presence

This APOE4 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE4 corresponding sequence by homologous recombination.

Mice

Pdgfra-CreERT2

Strain Name：C57BL/6JSmo-Pdgfraem(CreERT2)1Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-225036
Validation Data：Presence

CreERT2 expression cassette was knocked into the Pdgfra gene .

Mice

hPD-1/hTLR9

Strain Name：C57BL/6JSmo-Pdcd1tm1(hPDCD1)Tlr9 tm1(hTLR9)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190023

hPD-1(NM-HU-00015) was crossed with hTLR9(NM-HU-18016) to generate hPD-1/hTLR9.

Mice

Ly6a-2A-Cre

Strain Name：C57BL/6JSmo-Ly6aem1(2A-iCre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-190028
Validation Data：Presence

A 2A-iCre expression cassette was knocked into the Ly6a gene stop codon site.

Mice

hIL21R/hIL2RG

Strain Name：C57BL/6JSmo-Il21rtm1(hIL21R)Il2rgtm1(IL2RG)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220004

hIL21R(NM-HU-210031) was crossed with hIL2RG(NM-HU-200007) to generate hIL21R/hIL2RG mice.

Mice

Siglecf-DreERT2

Strain Name：C57BL/6JSmo-Siglecfem1(kozak-DreER-WPRE-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200202

A kozak-DreER-WPRE-pA expression cassette was knocked into the Siglecf gene start codon site.

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