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mouse

hPD-1/hPD-L1(BALB/c)

Strain Name：BALB/cJSmo-Pdcd1tm(hPDCD1)Cd274tm(hPD-L1)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220142

hPD-1(BALB/c)(NM-HU-190079) mice were crossed with hPD-L1(BALB/c ) (NM-HU-220028) mice to generate hPD-1/ hPD-L1(BALB/c) mice.

mouse

Nkx2-5-IRES-Cre

Strain Name：C57BL/6JSmo-Nkx2-5em1(IRES-Cre-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200152
Validation Data：Presence

A IRES-Cre-WPRE-polyA expression cassette was knocked into the Nkx2-5 gene stop codon site.

mouse

Chga-CreERT2

Strain Name：C57BL/6JSmo-Chgaem(CreERT2-Wpre-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-204993
Validation Data：Presence

CreERT2-Wpre-pA expression cassette was knocked into the Chga gene.

mouse

Crh-IRES-Cre

Strain Name：C57BL/6JSmo-Crhem1(IRES-iCre-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200104

A IRES-iCre-pA expression cassette was knocked into the Crh gene stop codon site. This strain exhibits ectopic expression, and its expression profile requires validation.

mouse

Mc4r-2A-Cre

Strain Name：C57BL/6JSmo-Mc4rem1(T2A-Cre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200220
Validation Data：Presence

A T2A-Cre expression cassette was knocked into the Mc4r gene stop codon site.

mouse

Slc6a11-CreERT2

Strain Name：C57BL/6JSmo-Slc6a11em1(CreERT2-polyA(SV40)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200130
Validation Data：Presence

A CreERT2-polyA expression cassette was knocked into the Slc6a11 gene start codon site. Slc6a11 encodes GAT3 (Gabt4), a sodium-dependent transporter that uptakes the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), which ends the GABA neurotransmission. When Slc6a11-CreERT2 mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in SLC6A11positive cells. Defects in Slc6a11 may result in epilepsy or behavioral and intellectual defects.

mouse

R26-CAG-LSL-hEML4/ALK*F1174L-Luc-tdTomato

Strain Name：C57BL/6JSmo-Gt(ROSA)26Sortm1(SA-2xpolyA-CAG-LSL-EML4-ALK(F1174L)-IRES-luciferase-2A-tdTomato)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-190010

A SA-2xpolyA-CAG-LSL-EML4-ALK(F1174L)-IRES-Luciferase-2A-tdTomato-WPRE-polyA cassette was inserted at the Rosa26 locus. When bred to a strain expressing Cre recombinase under control of various tissue specific promoters, Cre recombination deletes the LSL cassette and allows the expression of the EML4-ALK(F1174L) protein.

mouse

R26-CAG-LSL-hEGFR*L858R/T790M/C797S-IRES-Luc-2A-tdTomato

Strain Name：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-EGFR (L858R-T790M-C797S)-IRES-luciferase-2A-tdTomato)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190067

These mice harbor a CAG-LSL-EGFR (L858R-T790M-C797S)-IRES-luciferase-2A-tdTomato cassette in the Rosa26 locus generated by homologous recombination.

mouse

Stat3-Flox(in-frame mutation)

Strain Name：C57BL/6JSmo-Stat3em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200225

These mice carry loxP sites flanking exon 18-20 of Stat3 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Stat3 gene. The experimental strategy was designed with reference to the following publications: (PMID: 14566054; 17660847; 12571365). While Stat3-Flox(Stock No.NM-CKO-200050）mice carrying the loxP sites flanking exon 12-14 of Stat3 gene.

mouse

hPLK1

Strain Name：C57BL/6JSmo-Plk1tm1(hPLK1)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-225083

The endogenous mouse Plk1 gene was replaced by human PLK1 gene.

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