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Models

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Mice

hF12

Strain Name:C57BL/6Smoc-F12tm1(hF12)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-210017
Validation Data:Presence

The endogenous mice F12 gene was replaced by human F12 gene.

Mice

hIL1A

Strain Name:C57BL/6Smoc-Il1atm1(hIL1A)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-215071
Validation Data:Presence

The endogenous mouse Il1a gene was replaced by human IL1A gene.

Mice

hICOS

Strain Name:C57BL/6Smoc-Icostm1(hICOS)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-00052
Validation Data:Presence

The endogenous mouse Icos gene was replaced by human ICOS gene. While hICOS(2)(Stock No.NM-HU-190030) mice function similarly to hICOS mice,for more detailed information please contact our technical advisor.

Mice

Foxp3-DreERT2

Strain Name:C57BL/6Smoc-Foxp3em5(IRES-DreER)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-KI-200198

A IRES-DreER expression cassette was knocked into the Foxp3 gene stop codon site.

Mice

hPD-L1/hSIGLEC15

Strain Name:C57BL/6Smoc-Cd274tm1(hCD274)Siglec15tm1(hSIGLEC15)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-2000103

hPD-L1(NM-HU-00062) was crossed with hSIGLEC15(NM-HU-190037) to generate hPD-L1/hSIGLEC15.

Mice

R26-CAG-LSL-hPIK3CA*H1047R-IRES-Luc-2A-tdTomato

Strain Name:C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-LSL-PIK3CA(H1047R)-IRES-luciferase-2A-tdTomato)Smoc
Strain State:Repository Live | Cat. NO.:NM-KI-190065

These mice harbor a CAG-LSL-PIK3CA(H1047R)-IRES-luciferase-2A-tdTomato cassette in the Rosa26 locus generated by homologous recombination.

Mice

hSIRPA(2)/hCD47

Strain Name:C57BL/6Smoc-Sirpatm2(hSIRPA)Cd47tm1(hCD47)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-2000111
Validation Data:Presence

This SIRPA and CD47 double Knock-in strain is established by crossing hSIRPA and hCD47 mice together. These double double Knock-in mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.While hSIRPA/hCD47 (Stock No.NM-HU-190019) have been pulled from shelves for some reasons.

Mice

hSERPINC1

Strain Name:C57BL/6Smoc-Serpinc1tm1(hSERPINC1)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-225075
Validation Data:Presence

The endogenous mouse Serpinc1 gene was replaced by human SERPINC1 gene.

Mice

Il1a-Luc-2A-EGFP

Strain Name:C57BL/6Smoc-Il1aem1(Luc-eGFP)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-KI-00009
Validation Data:Presence

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon.

Mice

hSIGLEC10

Strain Name:C57BL/6Smoc-Siglecgtm1(hSIGLEC10)/Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-2000061
Validation Data:Presence

The endogenous mouse Siglecg gene was replaced by human SIGLEC10 gene.

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