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Models

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Mice

hPD-1/hIL1B

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Il1btm3(hIL1B)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210018

hPD-1(NM-HU-00015) was crossed with hIL1B(NM-HU-190047) to generate hPD-1/hIL1B mice

Mice

hHLA-DPB1*04: 01

Strain Name：C57BL/6Smoc-H2-Ab1em1(hHLA-DPB1*04: 01)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210011

The endogenous mice H2-Ab1 gene was replaced by human HLA-DPB1*04:01 gene.

Mice

Cd8a-2A-tdTomato-2A-Luc

Strain Name：C57BL/6Smoc-Cd8aem(T2A-tdTomato-P2A-Luciferase)1Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-225025

T2A-tdTomato-P2A-Luciferase expression cassette was knocked into the Cd8a gene .

Mice

hCTLA-4/hTIGIT

Strain Name：C57BL/6Smoc-Ctla4em1(hCTLA4)Tigitem1(hTIGIT)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210399

hCTLA4(NM-HU-00014) was crossed with hTIGIT(NM-HU-00053) to generate hCTLA4/hTIGIT mice.

Mice

Slc34a1-CreERT2

Strain Name：C57BL/6Smoc-Slc34a1em1(CreERT2-SV40pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-210110

CreERT2-SV40pA expression cassette was knocked into the Slc34a1 gene .

Mice

hSIRPA(2)/hCD47

Strain Name：C57BL/6Smoc-Sirpatm2(hSIRPA)Cd47em1(hCD47)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000111

This SIRPA and CD47 double Knock-in strain is established by crossing hSIRPA and hCD47 mice together. These double double Knock-in mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.While hSIRPA/hCD47 (Stock No.NM-HU-190019) have been pulled from shelves for some reasons.

Mice

hSERPINH1

Strain Name：C57BL/6Smoc-Serpinh1tm1(hSERPINH1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-225081

The endogenous mouse Serpinh1 gene was replaced by human SERPINH1 gene.

Mice

hIL11

Strain Name：C57BL/6Smoc-Il11em1(hIL11)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-204981

The endogenous mice Il11 gene was replaced by human IL11 gene.

Mice

hPD-1/hSEMA4D

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Sema4dem1(hSemA4D)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190033

hPD-1(NM-HU-00015) was crossed with hSEMA4D(NM-HU-00117) to generate hPD-1/hSEMA4D.

Mice

hTNFa-Tg

Strain Name：C57BL/6Smoc-Tgtn(hTNFa promoter-hTNFa-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-TG-200004

These transgenic mice harbor hTNFa promoter-hTNFa-pA expression cassette.

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