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Models

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Mice

hCTLA-4/4-1BB

Strain Name：C57BL/6Smoc-Ctla4em1(hCTLA4) Tnfrsf9em1(hTNFRSF9) /Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18020

This CTLA4 and 4-1BB double knockin strain is established by crossing CTLA4-HU and 4-1BB-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

Tert-CreERT2-2A-EGFP

Strain Name：C57BL/6Smoc-Tertem1(CreERT2-2A-GFP-WPRE-PA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18037

A CreERT2-2A-GFP-WPRE-PA expression cassette was knocked into the Telt gene start codon site by homologous recombination.

Mice

hIL2RA/hIL2RB/hIL2RG

Strain Name：C57BL/6Smoc-Il2ratm1(hIL2RA)Il2rgem1(IL2RG)Il2rbtm1(hIL2RB)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210414

hIL2RA(NM-HU-190064) was crossed with hIL2RG/hILRB(NM-HU-210354) to generate hIL2RA/hIL2RB/hIL2RG mice.

Mice

Avpr1a-KO

Strain Name：C57BL/6Smoc-Avpr1aem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-200043

Exon 1-2 of Avpr1a gene was deleted to generate Avpr1a knockout mice.

Mice

hFGL1

Strain Name：C57BL/6Smoc-Fgl1em1(hFGL1)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-225038

The endogenous mouse Fgl1 gene was replaced by human FGL1 gene.

Mice

C4b-KO

Strain Name：C57BL/6Smoc-C4bem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190761

Exon 3 of C4b gene was deleted to generate C4b knockout mice.

Mice

hCXCR4

Strain Name：C57BL/6Smoc-Cxcr4em1(hCXCR4)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000081

The endogenous mouse Cxcr4 gene was replaced by human CXCR4 gene.

Mice

Bmal1-Flox

Strain Name：C57BL/6Smoc-Bmal1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200063

These mice carry loxP sites flanking exon 8 of Bmal1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Bmal1 gene.

Mice

hCD73(2)

Strain Name：C57BL/6Smoc-Nt5etm3(NT5E)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200009

The endogenous mouse Nt5e gene was replaced by human NT5E gene.

Mice

Il17a-2A-CreERT2

Strain Name：C57BL/6Smoc-Il17aem1(2A-CreERT2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00059

A 2A-Cre cassette was inserted before stop codon of mouse Il17a gene which is known as a T cell marker.

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