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Models

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Mice

Ctsk-2A-Cre

Strain Name：C57BL/6Smoc-Ctskem1(2A-Cre-Wpre-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190019
Validation Data：Presence  |  Publications：1piece

The 2A-Cre-Wpre-polyA cassette is inserted before 3'UTR region of Ctsk gene.

Mice

hFCGR2A

Strain Name：C57BL/6Smoc-Fcgr2btm3(hFCGR2A)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000071
Validation Data：Presence

The endogenous mouse Fcgr2b gene was replaced by human FCGR2A gene.

Mice

hCD3E/hSDC1

Strain Name：C57BL/6Smoc-Cd3etm1(hCD3E)Sdc1tm1(hSDC1)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220021

hCD3E(NM-HU-00114) was crossed with hSDC1(NM-HU-2000026) to generate hCD3E/hSDC1 mice.

Mice

R26-CAG-LSL-hTM6SF2*E167K-EGFP

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(SA-Frt-2xpolyA-CAG-Frt-LSL-TM6SF2-IRES-GFP-WPRE-PA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200017

These mice harbor a SA-Frt-2xpolyA-CAG-Frt-LSL-TM6SF2-IRES-GFP-WPRE-PA cassette in the Rosa26 locus generated by homologous recombination.

Mice

hIGHG1

Strain Name：C57BL/6Smoc-Ighg1tm1(hIGHG1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-225091
Validation Data：Presence

The endogenous mouse Ighg1 gene was replaced by human IGHG1 gene.

Mice

hIFNGR2

Strain Name：C57BL/6Smoc-Ifngr2tm(hIFNGR2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-215010
Validation Data：Presence

The endogenous mouse Ifngr2 gene was replaced by human IFNGR2 gene.

Mice

Ctsk-2A-CreERT2

Strain Name：C57BL/6Smoc-Ctskem1(2A-CreERT2-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200067
Publications：1piece

A 2A-CreERT2-WPRE-polyA expression cassette was knocked into the Ctsk gene stop codon site.

Mice

hPD-L1/hVISTA

Strain Name：C57BL/6Smoc-Visrtm1(hVSIR)Cd274tm1(hCD274)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000094

hPD-L1(NM-HU-00062) was crossed with hVISTA(NM-HU-00118) to generate hPD-L1/hVISTA.

Mice

hFAS

Strain Name：C57BL/6Smoc-Fastm1(hTNFRSF6)/Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-210007
Validation Data：Presence

The endogenous mice Fas gene was replaced by human FAS gene.

Mice

hICOS/hICOSL

Strain Name：C57BL/6Smoc-Icosltm1(hICOSLG) Icostm1(hICOS)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18018
Validation Data：Presence

This ICOS and ICOSL double knockin strain is established by crossing ICOS-HU and ICOSL-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

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