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Models

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Mice

Sirt3-KO

Strain Name：C57BL/6Smoc-Sirt3em1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190368

This Sirt3 knockout mouse model was generated by knocking out the exon 2-3 region of the Sirt3.

Mice

Chga-CreERT2

Strain Name：C57BL/6Smoc-Chgaem(CreERT2-Wpre-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-204993
Validation Data：Presence

CreERT2-Wpre-pA expression cassette was knocked into the Chga gene.

Mice

Mesp1-CreERT2

Strain Name：C57BL/6Smoc-Mesp1em(CreERT2-Wpre-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-215087

CreERT2-Wpre-pA expression cassette was knocked into the Mesp1 gene .

Mice

hCD3EDG/hCD40

Strain Name：C57BL/6Smoc-Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)Cd40tm1(hCD40)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-220116

hCD3EDG(NM-HU-220120) mice were crossed with hCD40(NM-HU-00076) to generate hCD3EDG//hCD40 mice.

Mice

Meox1-Dre

Strain Name：C57BL/6Smoc-Meox1em1(Dre-Wpre-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200174

A Dre-Wpre-polyA expression cassette was knocked into the Meox1 gene start codon site.

Mice

hIGHA1

Strain Name：C57BL/6Smoc-sμtm1(hIGHA1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000086
Validation Data：Presence

The endogenous mouse sμ region was replaced by human IGHA1.

Mice

R26-CreERT2

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-FRT-2xpolyA-CAG-FRT-CreERT2-Rox-WPRE-Rox-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200041
Validation Data：Presence

These mice harbor a SA-FRT-2xpolyA-CAG-FRT-CreERT2-Rox-WPRE-Rox-polyA cassette in the Rosa26 locus generated by homologous recombination. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in multiple tissues after tamoxifen treatment.

Mice

hPD-1/hCD28

Strain Name：C57BL/6Smoc-Pdcd1tm1(hPDCD1)Cd28tm2(hCD28)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000097

hPD-1(NM-HU-00015) was crossed with hCD28(NM-HU-190011) to generate hPD-1/hCD28.

Mice

Il7r-Cre

Strain Name：C57BL/6Smoc-Il7rem1(Cre-Wpre-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200306
Validation Data：Presence

Cre-Wpre-pA expression cassette was knocked into the Il7r gene start codon site.

Mice

hLAG3/hCTLA-4

Strain Name：B6.129S-Lag3tm1(hLAG3)Ctla4tm1(hCTLA4)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190018

This LAG3 and CTLA4 double knockin strain is established by crossing LAG3-HU and CTLA4-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

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