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Models

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Mice

Etv1-CreERT2

Strain Name：C57BL/6Smoc-Etv1em1(CreERT2-SV40-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200105

A CreERT2 expression cassette was knocked into the Etv1 gene start codon site. ETV1 expression is enriched in fast conduction tissues of embryonic and adult mammalian hearts. And ETV1 expression is upregulated in the atrial tissue of patients with permanent atrial fibrillation. Etv-CreERT2 mice can be applied to heart disease research. ETV1 is also expressed in retinal ganglion cells of adult mice, and the mouse model can be used to study how retinal ganglion cells contribute to visual processing in the brain.

Mice

hNKG2A/hCD94

Strain Name：C57BL/6Smoc-Nkg2tm1(hNKG2A)Cd94tm1(hCD94)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000016

The endogenous mouse Nkg2 and Cd94 gene was replaced by human NKG2A and CD94 gene.

Mice

hSIRPA(2)/hCD47/hPD-1/hPD-L1

Strain Name：C57BL/6Smoc-Sirpatm2(hSIRPA)Cd47em1(hCD47)Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210358

hSIRPA(2)(NM-HU-18015)，hCD47（NM-HU-00050), hPD-1（NM-HU-00015）, hPD-L1（NM-HU-00062）was crossed together to generate hSIRPA(2)/hCD47/hPD-1/hPD-L1 mice.

Mice

hCD3EDG/hCD20(2)

Strain Name：C57BL/6Smoc-Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)Ms4a1tm2 (hCD20) /Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220119

hCD3EDG(NM-HU-220120) mice were crossed with hCD20(2)(NM-HU-200114) mice to generate hCD3EDG/hCD20(2).

Mice

R26-CAG-LSL-hEGFR*L858R/T790M-IRES-Luc-2A-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-EGFR (L858R-T790M)-IRES-luciferase-2A-tdTomato)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190068

These mice harbor a CAG-LSL-EGFR (L858R-T790M)-IRES-luciferase-2A-tdTomato cassette in the Rosa26 locus generated by homologous recombination.

Mice

Slc6a1-KO

Strain Name：B6;129S-Slc6a1tm1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-00002

Slc6a1-KO mice(Stock No.NM-KO-00002）carry a knockout allele derived from the targeted deletion of exon 2-3. While Slc6a1-KO(2) mice (Stock No.NM-KO-210290）carrying the exon 6 deletion. Slc6a1-KO(3) mice(Stock No.NM-KO-210126） carrying the exon 7 deletion.

Mice

Tlr5-CreERT2

Strain Name：C57BL/6Smoc-Tlr5em1(CreERT2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-215033

CreERT2 expression cassette was knocked into the Tlr5 gene.

Mice

Lrp1-Flox

Strain Name：C57BL/6Smoc-Lrp1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-2101319

These mice carry loxP sites flanking exon 7-8 of Lrp1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Lrp1 gene.

Mice

hCD3EDG/hCD19

Strain Name：C57BL/6Smoc-Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)Cd19em1(hCD19) /Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-220109

hCD3EDG(NM-HU-220120) mice were crossed with hCD19(NM-HU-00110) mice to generate hCD3EDG/hCD19 mice.

Mice

Sidt2-Flox

Strain Name：B6;129S-Sidt2tm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00041

The Sidt2 flox allele has loxP sites flanking exon 2 of Sidt2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

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