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Models

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Mice

MHC Class II(I-A/I-E)-KO(Nod-Scid)

Strain Name：NOD-PrkdcscidH2-Ab1em1H2-Aaem1H2-Eb1em1H2-Eb2em1H2-Ea-psem1Smoc
Strain State：Developing | Cat. NO.：NM-KO-18057

All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models. These MHC class II molecule-deficient mice were on the Nod-Scid genetic background and lacked cell surface expression of both class II-A and class II-E MHC proteins.

Mice

hKLRK1

Strain Name：C57BL/6Smoc-Klrk1em1(hKLRK1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190005

The endogenous mouse Klrk1 gene was replaced by human KLRK1 gene.

Mice

Pax8-Cre

Strain Name：C57BL/6Smoc-Pax8em1(Cre-WPRE-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200151

A Cre-WPRE-polyA expression cassette was knocked into the Pax8 gene start codon site.

Mice

Zap70-W163C(Balb/c)

Strain Name：BALB/cAnSmoc-Zap70em(W163C)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-210366

These mice carry a W163C mutation of Zap70 gene.

Mice

hIL2/hIL2RA(BALB/c)

Strain Name：BALB/cAnSmoc-Il2tm3(hIL2)Il2ratm1(hIL2RA)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220018

The endogenous mouse Il2 and Il2ra gene was replaced respectively by human IL2 and IL2RA gene.

Mice

R26-LNL-PB

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LNL-PB-V5)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00065

These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven piggyBac transposase. The targeted mutation was inserted into the Gt(ROSA)26Sor locus by homologous recombination. PiggyBac transposase is expressed when bred to mice that express Cre recombinase.

Mice

hICOS(2)

Strain Name：C57BL/6Smoc-Icosem2(hICOS)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190030

The endogenous mouse Icos gene was replaced by human ICOS gene. While hICOS(Stock No.NM-HU-00052) mice function similarly to hICOS(2) mice,for more detailed information please contact our technical advisor.

Mice

hGDF15

Strain Name：C57BL/6Smoc-Gdf15em(hGDF15)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-215002

The endogenous mice Gdf15 gene was replaced by human GDF15 gene.

Mice

hIL2

Strain Name：C57BL/6Smoc-Il2tm3(hIL2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190048

The endogenous mouse Il2 gene was replaced by human IL2 gene.

Mice

Slc6a1-S295L

Strain Name：C57BL/6Smoc-Slc6a1em2(S295L)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190014

These mice carry a p.S295L mutation in Slc6a1 gene .

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