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Models

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Mice

Trp53-Flox

Strain Name：C57BL/6Smoc-Trp53tm2(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-18005
Publications：1piece

These Trp53 flox mice possess loxP sites flanking exons 5-7 via ESC targeting. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

hTNFR2/hIL2RA

Strain Name：C57BL/6Smoc-Tnfrsf1btm2(hTNFRSF1B)Il2ratm1(hIL2RA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210408

hTNFRSF1B(NM-HU-190010) was crossed with hIL2RA(NM-HU-190064) to generate hTNFRSF1B/hIL2RA mice.

Mice

hHER3

Strain Name：C57BL/6Smoc-Erbb3tm1(hERBB3)Smoc
Strain State：Developing | Cat. NO.：NM-HU-200234

The endogenous mice Erbb3 gene was replaced by human HER3 gene.

Mice

Cd79a-2A-Cre

Strain Name：C57BL/6Smoc-Cd79aem(2A-Cre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-220089
Validation Data：Presence

2A-Cre expression cassette was knocked into the Cd79a gene stop codon site.

Mice

hPD-1/hPD-L1(2)/hCCR8

Strain Name：C57BL/6Smoc-Pdcd1tm1(hPDCD1)Cd274tm2(hPD-L1)Ccr8tm1(hCCR8)/Smoc
Strain State：Developing | Cat. NO.：NM-HU-210402

hPD-1(NM-HU-00015) and hPD-1(2)(NM-HU-190039) were crossed with hCCR8(NM-HU-190053) to generate hPD-1/hPD-L1(2)/hCCR8 mice.

Mice

Etv1-CreERT2

Strain Name：C57BL/6Smoc-Etv1em1(CreERT2-SV40-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200105
Validation Data：Presence

A CreERT2 expression cassette was knocked into the Etv1 gene start codon site. ETV1 expression is enriched in fast conduction tissues of embryonic and adult mammalian hearts. And ETV1 expression is upregulated in the atrial tissue of patients with permanent atrial fibrillation. Etv-CreERT2 mice can be applied to heart disease research. ETV1 is also expressed in retinal ganglion cells of adult mice, and the mouse model can be used to study how retinal ganglion cells contribute to visual processing in the brain.

Mice

hPD-L1/hSEMA4D

Strain Name：C57BL/6Smoc-Cd274tm1(hPD-L1)Sema4dtm1(hSemA4D)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190034

hPD-L1(NM-HU-00062) was crossed with hSEMA4D(NM-HU-00117) to generate hPD-L1/hSEMA4D.

Mice

Cd68-IRES-CreERT2

Strain Name：C57BL/6Smoc-Cd68em1(IRES-CreERT2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200162

A IRES-CreERT2 expression cassette was knocked into the Cd68 gene stop codon site.

Mice

hAPOE4

Strain Name：C57BL/6Smoc-Apoetm2(hAPOE4)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190002
Validation Data：Presence

This APOE4 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE4 corresponding sequence by homologous recombination.

Mice

S100a4-2A-CreERT2

Strain Name：C57BL/6Smoc-S100a4em1(2A-CreERT2-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200024
Validation Data：Presence

A 2A-CreERT2-WPRE-polyA expression cassette was knocked into the S100a4 gene stop codon site.

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