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Models

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Mice

hIFNGR1/hIFNGR2

Strain Name:C57BL/6Smoc-Ifngr1em3(hIFNGR1)Ifngr2tm(hIFNGR2)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-220003

hIFNGR1(NM-HU-190076) was crossed with hIFNGR2(NM-HU-215010) to generate hIFNGR1/hIFNGR2 mice.

Mice

R26-pAPOE-hCYP3A4(FVB)

Strain Name:FVB-Gt(ROSA)26Sorem1(pAPOE-CYP3A4)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-KI-18032

This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the liver-specific APOE promoter into the mouse Rosa26 site, which can be used to obtain liver-expressed CYP3A4 humanized model after mating with the Cyp3a13 gene and other Cyp3a family gene knockout mice. This model can be used with NM-KI-18033 mice which has gut-specific expression of human CYP3A4 to compare the contribution of intestinal versus hepatic metabolism to the biotransformation of a test article.

Mice

hIFNGR2

Strain Name:C57BL/6Smoc-Ifngr2tm(hIFNGR2)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-215010

The endogenous mouse Ifngr2 gene was replaced by human IFNGR2 gene.

Mice

hPD-1/hTLR9

Strain Name:C57BL/6Smoc-Pdcd1em1(hPDCD1)Tlr9 tm1(hTLR9)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-190023

hPD-1(NM-HU-00015) was crossed with hTLR9(NM-HU-18016) to generate hPD-1/hTLR9.

Mice

hIL11/hIL11RA

Strain Name:C57BL/6Smoc-Il11em1(hIL11)Il11ra1tm1(hIL11RA)/Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-210372

hIL11(NM-HU-204981) was crossed with hIL11RA (NM-HU-204982) to generate hIL11/hIL11RA mice.

Mice

Nphs2-CreERT2

Strain Name:C57BL/6Smoc-Nphs2tm1(IRES-CreERT2)Smoc
Strain State:Repository Live | Cat. NO.:NM-KI-00128

An IRES-CreERT2 co-expression cassette is inserted into 3'UTR region of Nphs2 gene via homologous recombination to establish a tamoxifen inducible Nphs2-CreERT2 tool stain.

Mice

hSIGLEC8

Strain Name:C57BL/6Smoc-Sigleceem1(hSIGLEC8)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-204983

The endogenous mice Siglece gene was replaced by human SIGLEC8 gene. While hSIGLEC8(2)(Stock No.NM-HU-210033) mice function similarly to hSIGLEC8 mice,for more detailed information please contact our technical advisor.

Mice

Il10-KO(BALB/c)

Strain Name:BALB/cAnSmoc-Il10em4Smoc
Strain State:Repository Live | Cat. NO.:NM-KO-200637

Exon 1-5 of Il10 gene was deleted to generate Il10 knockout mice.

Mice

Tie1-2A-Cre

Strain Name:C57BL/6Smoc-Tie1em1(2A-Cre)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-KI-18023

A 2A-Cre coexpression cassette is inserted befor the stop codon of mouse Tie1 gene via homologous recombination to establish a tamoxifen inducible Tie1-Cre tool stain. This strain can be used to knockout target gene in Tie1+ cells when crossed with mice which carry loxp sites flanking target gene.

Mice

hIL13

Strain Name:C57BL/6Smoc-Il13em2(hIL13)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-190069

The endogenous mouse Il13 gene was replaced by human IL13 gene.

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