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Models

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Mice

hPD-1/hTIM3

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Havcr2em1(hHAVCR2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00103

hPD-1(NM-HU-00015) was crossed with hTIM3(NM-HU-00054)to generate hPD-1/hTIM3 mice

Mice

hDLL4

Strain Name：C57BL/6Smoc-Dll4tm1(hDLL4)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000020

The endogenous mouse Dll4 gene was replaced by human DLL4 gene.

Mice

Shh-CreERT2

Strain Name：C57BL/6Smoc-Shhem1(CreERT2-WPRE-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200145

A  CreERT2-WPRE-polyA expression cassette was knocked into the Shh gene start codon site. Expression of Shh-CreERT2 may be "leaky" at 1-month-old mice without tamoxifen.

Mice

a-IRES-Cre

Strain Name：C57BL/6Smoc-atm1(Cre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200027

A IRES-Cre expression cassette was knocked into the a gene stop codon site via ESC targeting. Male mice with a germline Cre leak expression condition, please use female mice and flox mice for breeding crosses. References are available, please see the website for details.

Mice

hCXCR5

Strain Name：C57BL/6Smoc-Cxcr5em(hCXCR5)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-215007

The endogenous mice Cxcr5 gene was replaced by human CXCR5 gene.

Mice

Ascl1-CreERT2

Strain Name：C57BL/6Smoc-Ascl1em1(CreERT2-Wpre-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200207

A CreERT2-Wpre-pA expression cassette was knocked into the Ascl1 gene start codon site.

Mice

hPTPN1

Strain Name：C57BL/6Smoc-Ptpn1tm1(hPTPN1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-225059

The endogenous mouse Ptpn1 gene was replaced by human PTPN1 gene.

Mice

hIl5

Strain Name：C57BL/6Smoc-Il5tm3(hIL5)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190001

This IL5 humanized mouse model was established by replacing the mouse Il5 gene coding exons and introns with the human TLR9 corresponding sequence by homologous recombination.

Mice

hCXCR3

Strain Name：C57BL/6Smoc-Cxcr3em1(hCXCR3)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-200219

The endogenous mouse Cxcr3 gene was completely or partially replaced by human CXCR3 gene via ESC targeting.

Mice

hSOD1

Strain Name：C57BL/6Smoc-Sod1tm1(hSOD1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-225056

The endogenous mouse Sod1 gene was replaced by human SOD1 gene.

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