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Models

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Mice

hCTLA-4/hTIGIT

Strain Name：C57BL/6Smoc-Ctla4em1(hCTLA4)Tigitem1(hTIGIT)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210399

hCTLA4(NM-HU-00014) was crossed with hTIGIT(NM-HU-00053) to generate hCTLA4/hTIGIT mice.

Mice

Slc34a1-CreERT2

Strain Name：C57BL/6Smoc-Slc34a1em1(CreERT2-SV40pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-210110

CreERT2-SV40pA expression cassette was knocked into the Slc34a1 gene .

Mice

hSIRPA(2)/hCD47

Strain Name：C57BL/6Smoc-Sirpatm2(hSIRPA)Cd47em1(hCD47)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000111

This SIRPA and CD47 double Knock-in strain is established by crossing hSIRPA and hCD47 mice together. These double double Knock-in mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.While hSIRPA/hCD47 (Stock No.NM-HU-190019) have been pulled from shelves for some reasons.

Mice

hSERPINH1

Strain Name：C57BL/6Smoc-Serpinh1tm1(hSERPINH1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-225081

The endogenous mouse Serpinh1 gene was replaced by human SERPINH1 gene.

Mice

Il1b-Luc-Tg

Strain Name：B6.Cg-Tg(IL1B-luc)Smoc
Strain State：Repository Live | Cat. NO.：NM-TG-00001

The transgenic mice model could be used to study transcriptional regulation of the IL-1βgene expression in the inflammatory process and evaluation the effect of anti-inflammatory drug in vivo.

Mice

hIL11

Strain Name：C57BL/6Smoc-Il11em1(hIL11)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-204981

The endogenous mice Il11 gene was replaced by human IL11 gene.

Mice

hPD-1/hSEMA4D

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Sema4dem1(hSemA4D)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190033

hPD-1(NM-HU-00015) was crossed with hSEMA4D(NM-HU-00117) to generate hPD-1/hSEMA4D.

Mice

hTNFa-Tg

Strain Name：C57BL/6Smoc-Tgtn(hTNFa promoter-hTNFa-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-TG-200004

These transgenic mice harbor hTNFa promoter-hTNFa-pA expression cassette.

Mice

hCD93

Strain Name：C57BL/6Smoc-Cd93em1(hCD93)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-215065

The endogenous mouse Cd93 gene was replaced by human CD93 gene.

Mice

A2ml1-Flox

Strain Name：C57BL/6Smoc-A2ml1em1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of A2ml1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of A2ml1 gene.

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