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Models

About 181 results
Mice

Rag1-KO(Rag1-EGFP)

Strain Name：B6;129S-Rag1tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00069

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag1 gene start codon site. As a Rag1 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag1 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

Rag2-KO(Rag2-EGFP)

Strain Name：B6;129S-Rag2tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00070

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag2 gene start codon site. As a Rag2 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag2 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

Rag2-KO

Strain Name：C57BL/6Smoc-Rag2em2Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190429

Partial exon 3 of Rag2 gene was deleted to generate Rag2 knockout mice. Deletion of this region will cause frameshift and result in loss of function of mouse Rag2 gene.

Mice

H11-CAG-LSL-Myc

Strain Name：C57BL/6Smoc-Igs2em1(CAG-LSL-Myc)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00039

The c-Myc gene (also known as Myc) is abnormally expressed in many tumors and plays a critical role in the regulation of cell proliferation, growth and metabolism, gene instability, stimulation of angiogenesis, malignant transformation, cell differentiation and apoptosis. These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Myc oncogene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination. Myc is expressed when bred to mice that express Cre recombinase.

Mice

Cdkn2a-KO(p19-KO)

Strain Name：C57BL/6Smoc-Cdkn2aem2Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190633

Cdkn2a(p19) gene knockout mouse model was established by knockout exon1 of Cdkn2a-p19ARF transcript (Cdkn2a-202 transcript).

Mice

Mbd2-KO

Strain Name：C57BL/6Smoc-Mbd2em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190114

This Mbd2 knockout mouse model was generated by knocking out the exon 2 region of the Mbd2 .

Mice

Cd68-KO

Strain Name：C57BL/6Smoc-Cd68em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190045

This Cd68 knockout mouse model was generated by knocking out the exon 3-4 region of the Cd68 .

Mice

Ceacam1-KO

Strain Name：C57BL/6Smoc-Ceacam1em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190054

This Ceacam1 knockout mouse model was generated by knocking out the exon 2-6 region of the Ceacam1 .

Mice

Smyd3-KO

Strain Name：C57BL/6Smoc-Smyd3em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190379

This Smyd3 knockout mouse model was generated by knocking out the exon2 region of the Smyd3.

Mice

Csf1-KO

Strain Name：C57BL/6Smoc-Csf1em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190063

This Csf1 knockout mouse model was generated by knocking out the exon 4-5 region of the Csf1 .

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