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Models

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Mice

hNR1I3

Strain Name：C57BL/6Smoc-Nr1i3tm2(hNR1I3)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200253
Validation Data：Presence

The endogenous mice Nr1i3 gene was replaced by human NR1I3 gene.

Mice

hCD3EDG/hCD40

Strain Name：C57BL/6Smoc-Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)Cd40tm1(hCD40)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-220116

hCD3EDG(NM-HU-220120) mice were crossed with hCD40(NM-HU-00076) to generate hCD3EDG//hCD40 mice.

Mice

hIGHA1

Strain Name：C57BL/6Smoc-sμtm1(hIGHA1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000086
Validation Data：Presence

The endogenous mouse sμ region was replaced by human IGHA1.

Mice

hPD-1/hCD28

Strain Name：C57BL/6Smoc-Pdcd1tm1(hPDCD1)Cd28tm2(hCD28)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000097

hPD-1(NM-HU-00015) was crossed with hCD28(NM-HU-190011) to generate hPD-1/hCD28.

Mice

hLAG3/hCTLA-4

Strain Name：B6.129S-Lag3tm1(hLAG3)Ctla4tm1(hCTLA4)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190018

This LAG3 and CTLA4 double knockin strain is established by crossing LAG3-HU and CTLA4-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hCD3EDG/hCD38(2)

Strain Name：C57BL/6Smoc-Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)Cd38tm2(hCD38)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220114

hCD3EDG(NM-HU-220120) mice were crossed with hCD38(2)((NM-HU-190059) to generate hCD3EDG/hCD38 mouse.

Mice

hTIGIT/hCCR8

Strain Name：C57BL/6Smoc-Tigittm1(hTIGIT)Ccr8tm1(hCCR8)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210426

hTIGIT(NM-HU-00053) was crossed with hCCR8(NM-HU-190053) to generate hTIGIT/hCCR8 mice.

Mice

hFCGR2B/hOX40

Strain Name：C57BL/6Smoc-Fcgrt2Btm2(hFCGRT2B)Tnfrsf4tm1(hTNFRSF4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200265
Validation Data：Presence

hFCGR2B（NM-HU-2000010） was crossed with hOX40（NM-HU-00041）to generate hFCGR2B/hCD40 mice

Mice

hPD-1/hPD-L1/hLAG3

Strain Name：C57BL/6Smoc-Pdcd1tm1(hPDCD1)Cd274tm1(hPD-L1)Lag3tm1(hLAG3)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190028

hPD-1(NM-HU-00015),hPD-L1(NM-HU-00062) were crossed with hLAG3(NM-HU-00049) to generate hPD-1/hPD-L1/hLAG3.

Mice

hNR3C1

Strain Name：C57BL/6Smoc-Nr3c1tm1(hNR3C1)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-225058

The endogenous mouse Nr3c1 gene was replaced by human NR3C1 gene.

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