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Models

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Mice

hGDF15

Strain Name：C57BL/6Smoc-Gdf15tm(hGDF15)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-215002
Validation Data：Presence

The endogenous mice Gdf15 gene was replaced by human GDF15 gene.

Mice

hPD-1/hLAG3

Strain Name：C57BL/6Smoc-Pdcd1tm1(hPDCD1)Lag3tm1(hLAG3)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00101

hPD-1(NM-HU-00015) was crossed with hLAG3(NM-HU-00049)to generate hPD-1/hLAG3 mice

Mice

hCYP2D

Strain Name：C57BL/6Smoc-Cyp2dtm(hCYP2D)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-215016

The endogenous mouse Cyp2d gene was replaced by human CYP2D gene.

Mice

hCXCR3

Strain Name：C57BL/6Smoc-Cxcr3tm1(hCXCR3)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-200219
Validation Data：Presence

The endogenous mouse Cxcr3 gene was completely or partially replaced by human CXCR3 gene via ESC targeting.

Mice

hIl5

Strain Name：C57BL/6Smoc-Il5tm3(hIL5)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190001
Validation Data：Presence

This IL5 humanized mouse model was established by replacing the mouse Il5 gene coding exons and introns with the human TLR9 corresponding sequence by homologous recombination.

Mice

hIL18BP

Strain Name：C57BL/6Smoc-Il18bptm1(hIL18BP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210039
Validation Data：Presence

The endogenous mice Il18bp gene was replaced by human IL18BP gene.

Mice

hTNFR2/hIL2RA

Strain Name：C57BL/6Smoc-Tnfrsf1btm2(hTNFRSF1B)Il2ratm1(hIL2RA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210408

hTNFRSF1B(NM-HU-190010) was crossed with hIL2RA(NM-HU-190064) to generate hTNFRSF1B/hIL2RA mice.

Mice

hHER3

Strain Name：C57BL/6Smoc-Erbb3tm1(hERBB3)Smoc
Strain State：Developing | Cat. NO.：NM-HU-200234

The endogenous mice Erbb3 gene was replaced by human HER3 gene.

Mice

hPD-1/hPD-L1(2)/hCCR8

Strain Name：C57BL/6Smoc-Pdcd1tm1(hPDCD1)Cd274tm2(hPD-L1)Ccr8tm1(hCCR8)/Smoc
Strain State：Developing | Cat. NO.：NM-HU-210402

hPD-1(NM-HU-00015) and hPD-1(2)(NM-HU-190039) were crossed with hCCR8(NM-HU-190053) to generate hPD-1/hPD-L1(2)/hCCR8 mice.

Mice

hPD-L1/hSEMA4D

Strain Name：C57BL/6Smoc-Cd274tm1(hPD-L1)Sema4dtm1(hSemA4D)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190034

hPD-L1(NM-HU-00062) was crossed with hSEMA4D(NM-HU-00117) to generate hPD-L1/hSEMA4D.

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