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Mice

Axin2-CreERT2

Strain Name：C57BL/6Smoc-Axin2em1(CreERT2-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200109

A CreERT2-pA expression cassette was knocked into the Axin2 gene start codon site. As Axin2 is an intracellular protein, it is essential for identifying a surface marker for stem cell purification. When these Axin2-CreERT2 mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Axin2 expressing cells.

Mice

Bhlha15-CreERT2(2)

Strain Name：C57BL/6Smoc-Bhlha15em2(kozak-CreERT2-WPRE-polyA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200158

A kozak-CreERT2-WPRE-polyA expression cassette was knocked into the Bhlha15 gene start codon site. While Bhlha15-CreERT2 (Stock No. NM-KI-200080) mice were generated through replacing the coding region of Bhlha15 gene with a CreERT2 expression cassette.

Mice

Ucp1-CreERT2

Strain Name：C57BL/6Smoc-Ucp1em1(Kozak-CreERT2-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-190102

A Kozak-CreERT2-WPRE-polyA expression cassette was knocked into the Ucp1 gene start codon site.

Mice

Bhlha15-CreERT2

Strain Name：C57BL/6Smoc-Bhlha15em1(CreERT2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200080

The coding region of Bhlha15 gene was replaced by a CreERT2 expression cassette.Besides,a kozak-CreERT2-WPRE-polyA expression cassette were knock into the Bhlha15 gene start codon site to generate Bhlha15-CreERT2(2)(Stock No. NM-KI-200158) mice. Bhlha15(basic helix-loop-helix family member a15) is also known as Mist1. The gene product is involved in controlling exocrine secretion from the pancreas, small intestine and stomach. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Bhlha15.

Mice

Tert-CreERT2-2A-EGFP

Strain Name：C57BL/6Smoc-Tertem1(CreERT2-2A-GFP-WPRE-PA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18037

A CreERT2-2A-GFP-WPRE-PA expression cassette was knocked into the Telt gene start codon site by homologous recombination.

Mice

Wt1-CreERT2

Strain Name：C57BL/6Smoc-Wt1em1(CreERT2-WPRE-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200127

A CreERT2-WPRE-pA expression cassette was knocked into the Wt1 gene start codon site.

Mice

Shh-CreERT2

Strain Name：C57BL/6Smoc-Shhem1(CreERT2-WPRE-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200145

A  CreERT2-WPRE-polyA expression cassette was knocked into the Shh gene start codon site. Expression of Shh-CreERT2 may be "leaky" at 1-month-old mice without tamoxifen.

Mice

Ascl1-CreERT2

Strain Name：C57BL/6Smoc-Ascl1em1(CreERT2-Wpre-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200207

A CreERT2-Wpre-pA expression cassette was knocked into the Ascl1 gene start codon site.

Mice

Gli1-CreERT2

Strain Name：C57BL/6Smoc-Gli1em1(CreERT2-Wpre-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200073

A CreERT2-Wpre-polyA expression cassette was knocked into the Gli1 gene start codon site. Gli1 encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. When these Gli1-CreERT2 mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Gli1 expressing cells; making them useful for studying axis patterning, proliferation, and cell fate specification of Hedgehog responding cells at different stages of embryogenesis.

Mice

Slc17a6-CreERT2

Strain Name：C57BL/6Smoc-Slc17a6em2(CreERT2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-190011

This tamoxifen-inducible Slc17a6-CreERT2 tool mouse model was established by inserting a 2A-CreERT2-WPRE-polyA co-expression cassette into the stop codon of Slc17a6 gene.

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