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Models

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Mice

hSIRPA(2)/hCD47

Strain Name：C57BL/6Smoc-Sirpatm2(hSIRPA)Cd47tm1(hCD47)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000111
Validation Data：Presence

This SIRPA and CD47 double Knock-in strain is established by crossing hSIRPA and hCD47 mice together. These double double Knock-in mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.While hSIRPA/hCD47 (Stock No.NM-HU-190019) have been pulled from shelves for some reasons.

Mice

hSERPINC1

Strain Name：C57BL/6Smoc-Serpinc1tm1(hSERPINC1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-225075
Validation Data：Presence

The endogenous mouse Serpinc1 gene was replaced by human SERPINC1 gene.

Mice

Il1a-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il1aem1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00009
Validation Data：Presence

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon.

Mice

hSIGLEC10

Strain Name：C57BL/6Smoc-Siglecgtm1(hSIGLEC10)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000061
Validation Data：Presence

The endogenous mouse Siglecg gene was replaced by human SIGLEC10 gene.

Mice

Pax7-IRES-Cre

Strain Name：C57BL/6Smoc-Pax7em1(IRES-iCre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200120
Validation Data：Presence

A IRES-iCre expression cassette was knocked into the Pax7 gene stop codon site. Pax7 is expressed in myogenic progenitor cells. Pax7 is essential for the myogenic potential, survival, and proliferation of myogenic progenitors. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Pax7.

Mice

Cd19-2A-DreERT2

Strain Name：C57BL/6Smoc-Cd19em(2A-DreERT2-Wpre-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-215084

2A-DreERT2-Wpre-pA expression cassette was knocked into the Cd19 gene .

Mice

Aldob-KO

Strain Name：C57BL/6Smoc-Aldobem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-200602

Exon 3-6 of Aldob gene was deleted to generate Aldob knockout mice.

Mice

Ifnar1-KO

Strain Name：C57BL/6Smoc-Ifnar1em1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-18038

The Ifnar1 knockout mouse model was obtained by knocking out the exon 3-11 region of mouse Ifnar1 gene.

Mice

hPD-1/hTLR9

Strain Name：C57BL/6Smoc-Pdcd1tm1(hPDCD1)Tlr9 tm1(hTLR9)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190023

hPD-1(NM-HU-00015) was crossed with hTLR9(NM-HU-18016) to generate hPD-1/hTLR9.

Mice

Aadacl2fm1-Flox

Strain Name：C57BL/6Smoc-Aadacl2fm1em1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-253840

These mice carry loxP sites flanking exon 5 of Aadacl2fm1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Aadacl2fm1 gene.

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