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Models

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Mice

R26-CAG-LSL-hHER2-IRES-Luc-2A-EGFP

Strain Name:C57BL/6Smoc-Gt(ROSA)26Sortm1(SA-2xpolyA-CAG-LSL-HER2-luciferase-EGFP)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-KI-190008

A SA-2xpolyA-CAG-LSL-HER2-IRES-Luciferase-2A-EGFP-WPRE-polyA cassette was inserted at the Rosa26 locus. When bred to a strain expressing Cre recombinase under control of various tissue specific promoters, Cre recombination deletes the LSL cassette and allows the expression of the HER2 protein.

Mice

hMELTF

Strain Name:C57BL/6Smoc-Meltftm(hMELTF)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-215011
Validation Data:Presence

The endogenous mouse Meltf gene was replaced by human MELTF gene.

Mice

hPSGL-1(2)

Strain Name:C57BL/6Smoc-Selplgtm2(hSELPLG)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-210026
Validation Data:Presence

The endogenous mice Selplg gene was completely or partially replaced by human SELPLG gene via CRISPR/Cas9 mediated recombination.

Mice

hPD-1/hSTING

Strain Name:C57BL/6Smoc-Tmem173tm1(hTMem173)Pdcd1tm1(hPDCD1)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-2000104

hPD-1(NM-HU-00015) was crossed with hSTING(NM-HU-190036) to generate hPD-1/hSTING.

Mice

hPD-L1/hCTLA-4

Strain Name:C57BL/6Smoc-Ctla4tm1(hCTLA4)Cd274tm1(hPD-L1)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-00102
Validation Data:Presence

hPD-L1(NM-HU-00062) was crossed with hCTLA4(NM-HU-00014)to generate hPD-1/hCTLA4 mice

Mice

hDDR1

Strain Name:C57BL/6Smoc-Ddr1tm3(hDDR1)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-225086
Validation Data:Presence

The endogenous mouse Ddr1 gene was replaced by human DDR1 gene.

Mice

hPVRL2

Strain Name:C57BL/6Smoc-Nectin2tm1(hNECTIN2)/Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-2000084
Validation Data:Presence

The endogenous mouse Nectin2 gene was replaced by human PVRL2 gene.

Mice

AA467197-Flox

Strain Name:C57BL/6Smoc-AA467197em1(flox)Smoc
Strain State:Repository Live | Cat. NO.:NM-CKO-253746

These mice carry loxP sites flanking exon 1-3 of AA467197 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of AA467197 gene.

Mice

hAPOE3

Strain Name:C57BL/6Smoc-Apoetm3(hAPOE3)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-190003
Validation Data:Presence

This APOE3 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE3 corresponding sequence by homologous recombination.

Mice

Casp8-Flox

Strain Name:C57BL/6Smoc-Casp8em1(flox)Smoc
Strain State:Repository Live | Cat. NO.:NM-CKO-190003

These Casp8 flox mice possess loxP sites flanking exons 4. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

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