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Models

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Mice

Ptf1a-CreERT2

Strain Name：C57BL/6Smoc-Ptf1aem1(CreERT2-WPRE-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200118

A CreERT2-WPRE-pA expression cassette was knocked into the Ptf1a gene start codon site.

Mice

hIL1RL2

Strain Name：C57BL/6Smoc-Il1rl2em1(hIL1RL2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-215057

The endogenous mouse Il1rl2 gene was replaced by human IL1RL2 gene.

Mice

hNR1I2

Strain Name：C57BL/6Smoc-Nr1i2em3(hNR1I2)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000066

The endogenous mouse Nr1i2 gene was replaced by human NR1I2 gene.

Mice

hMARCO

Strain Name：C57BL/6Smoc-Marcoem1(hMARCO)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000029

The endogenous mouse Marco gene was replaced by human MARCO gene.

Mice

Atp4b-IRES-CreERT2(2)

Strain Name：C57BL/6Smoc-Atp4bem2(IRES-CreERT2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-210119

An IRES-CreERT2 expression cassette was knocked into the Atp4b gene stop codon site. Besides,An IRES-CreERT2-WPRE-pA expression cassette were knock into the Atp4b gene start codon site to generate Atp4b-IRES-CreERT2(Stock No. NM-KI-210118) mice. ATP4B could serve as a tumor suppressor in the tumorigenesis and progression. This strain is useful in studying the function of gastric parietal cells in gastric epithelial homeostasis. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cre-expressing cells after tamoxifen treatment.

Mice

hCTLA-4(2)

Strain Name：C57BL/6Smoc-Ctla4em2(hCTLA4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190038

Extracellular domain of mouse Ctla4 gene was replaced by human CTLA4 gene. While hCTLA4(Stock No.NM-HU-00014) mice function similarly to hCTLA4(2) mice,for more detailed information please contact our technical advisor.

Mice

Tyro3-KO

Strain Name：C57BL/6Smoc-Tyro3em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200558

Exon 3 of Tyro3 gene was deleted to generate Tyro3 knockout mice.

Mice

Etv1-CreERT2

Strain Name：C57BL/6Smoc-Etv1em1(CreERT2-SV40-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200105

A CreERT2 expression cassette was knocked into the Etv1 gene start codon site. ETV1 expression is enriched in fast conduction tissues of embryonic and adult mammalian hearts. And ETV1 expression is upregulated in the atrial tissue of patients with permanent atrial fibrillation. Etv-CreERT2 mice can be applied to heart disease research. ETV1 is also expressed in retinal ganglion cells of adult mice, and the mouse model can be used to study how retinal ganglion cells contribute to visual processing in the brain.

Mice

hNKG2A/hCD94

Strain Name：C57BL/6Smoc-Nkg2tm1(hNKG2A)Cd94tm1(hCD94)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000016

The endogenous mouse Nkg2 and Cd94 gene was replaced by human NKG2A and CD94 gene.

Mice

hSIRPA(2)/hCD47/hPD-1/hPD-L1

Strain Name：C57BL/6Smoc-Sirpatm2(hSIRPA)Cd47em1(hCD47)Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210358

hSIRPA(2)(NM-HU-18015)，hCD47（NM-HU-00050), hPD-1（NM-HU-00015）, hPD-L1（NM-HU-00062）was crossed together to generate hSIRPA(2)/hCD47/hPD-1/hPD-L1 mice.

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