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Models

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Mice

FcγR-KO(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1Fcgr2bemFcgr3emFcgr4emFcer1gem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-252414

By knocking out exon1-8 of the Fcgr2b gene, exon1-5 of the Fcgr3 gene, and exon1-5 of the Fcgr4 gene, and introducing mutations into exon 1 of the Fcer1g gene, Fcgr2b, Fcgr3, Fcgr4, and Fcer1g gene knockout mouse models were established.

Mice

NMG

Strain Name：NOD.Cg-PrkdcscidIl2rgem1Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-001
Validation Data：Presence  |  Publications：59piece

Prkdc and Il2rg genes were both knocked-out in NOD mice. Lacking mature T, B and NK cells; Low immune rejection against human cells and tissues; Good tumorigenicity so that a small number of cells can form tumors; Significant improvement in the survival of transplanted human cells and tissues; Suitable for the transplantation of human hematopoietic stem cells and the preparation of humanized mouse models; Suitable as the carrier mice for the transplantation of heterologous cells and tissues.

Mice

hβA

Strain Name：C57BL/6Smoc-Hbb-bs＆Hbb-bttm1(hHBG1，hHBB)Smoc
Strain State：Developing | Cat. NO.：NM-HU-253365

By using homologous recombination, the mouse Hbb-bs and Hbb-bt genes were subjected to humanization modification (the human genes being: HBA1 and HBA2).

Mice

hβS

Strain Name：C57BL/6Smoc-Hbb-bs＆Hbb-bttm1(hHBG1,hHBB-E7V)Smoc
Strain State：Developing | Cat. NO.：NM-HU-253366

By using homologous recombination, the mouse Hbb-bs and Hbb-bt genes were subjected to humanization modification (the human genes being: HBG1 and HBB).

Mice

hIL13/hIL4/hIL4R

Strain Name：C57BL/6Smoc-Il4tm3(hIL4)Il4ratm1(hIL4R)Il13tm3(hIL13)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-251863

Based on the hIL4/hIL4R(NM-HU-2000106) strain, the endogenous mouse Il13 gene was replaced by human IL13 gene.

Mice

NOD SCID

Strain Name：NOD.Cg-Prkdcscid/NifdcSmoc
Strain State：Repository Live | Cat. NO.：SM-019
Validation Data：Presence

The strain was developed on background of non-obese diabetic (NOD) mouse with spontaneous scid mutation. NOD SCID mouse, insusceptible to diabetes, possesses reduced activity of T cells and B cells, and defect in innate immunity.NOD SCID mouse is compatible with a wider range of engraftment of cell lines in comparison with nude mouse; And it is broadly applied to construction of PDX models. However, due to a short life span(8-9 months) caused by lethal thymic lymphomas, it is unsuitable for long-term in vivo assays.

Mice

R26-CAG-FLEX-Zbp1-Mouse-L-3xFLAG

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-loxP-STOP-lox2272-3xFLAG-Zbp1-Mouse-L-Kozak-loxP-lox2272-WPRE-bGH-pA)Smoc
Strain State：Developing | Cat. NO.：NM-KI-250273

The CAG-loxP-STOP-lox2272-3xFLAG-Zbp1-Mouse-L-Kozak-loxP-lox2272-WPRE-bGH-pA expression cassette was knocked into the R26 locus.

Mice

Ncr1-2A-Cre

Strain Name：C57BL/6Smoc-Ncr1em2(2A-iCre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-190027
Validation Data：Presence

A 2A-iCre expression cassette was knocked into the Ncr1 gene stop codon site.

Mice

Ncr1-IRES-mtagBFP2-Luc

Strain Name：C57BL/6Smoc-Ncr1em5(IRES-mtagBFP-luciferase)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200030
Validation Data：Presence

A IRES-mtagBFP-luciferase expression cassette was knocked into the Ncr1 gene stop codon site.

Mice

hPD-1

Strain Name：C57BL/6Smoc-Pdcd1tm1(hPDCD1) /Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00015
Validation Data：Presence  |  Publications：1piece

The endogenous mouse Pdcd1 gene was replaced by human PDCD1(PD-1) gene .

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