Cdkn2b-KO(p15-KO)
Nomenclature
C57BL/6Smoc-Cdkn2Bem1Smoc
Cat. NO.
NM-KO-190621
Strain State
Embryo cryopreservation
Gene Summary
Gene Symbol
Cdkn2b
Model Description
Exon 2 of Cdkn2b gene was deleted to generate Cdkn2b knockout mice.
Research Application：This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression.
*Literature published using this strain should indicate: Cdkn2b-KO(p15-KO) mice (Cat. NO. NM-KO-190621) were purchased from Shanghai Model Organisms Center, Inc..
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