hMAPT-P301S

Nomenclature

C57BL/6Smoc-Maptem1hMAPT-P301SSmoc

Cat. NO.

NM-KI-233262

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Mapt

Model Description

These strains carry a P301S mutation of hMAPT gene.

Validation Data

image.png

Fig.1 Detection of hMAPT-P301S expression in brain by RT-PCR. 

Wild type: only one band at 245 bp with primers F1/R1 (mMapt);

Heterozygous: one band at 245 bp with primers F1/R1 (hMAPT).

Abbr. M, DNA marker;  HE, heterozygous; WT, wild type.

image.png

Fig.2 Sequencing results of the MAPT locus in the wild type and heterozygous hMAPT-P301S mice.

image.png

Fig.3 Detection of Phospho-Tau expression in brain in hMAPT-P301S mice by WB. The relative gray values to GAPDH were quantitated by densitometry using ImageJ software.

Abbr. M, marker; WT, wild type; HO, homozygous.

Note. UnPaired t-test, *P < 0.01.



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