R26-CAG-LSL-hPLA2R1-IRES-EGFP
Nomenclature
C57BL/6Smoc-Gt(ROSA)26Sorem(CAG-LSL-hPLA2R1-IRES-EGFP)Smoc
Cat. NO.
NM-KI-220264
Strain State
Repository Live
Gene Summary
Gene Symbol
Gt(ROSA)26Sor
Model Description
Validation Data
Fig.1 Mice overexpressing hPLA2R1 exhibited slower body weight gain and increased mortality (n=12~20/group).
Fig.2 Urinary biochemical results.
hPLA2R1-overexpressing mice exhibited urinary biochemical abnormalities starting at 4 weeks of age (n=7/group).
Fig.3 Blood biochemical results.
hPLA2R1-overexpressing mice exhibited blood biochemical abnormalities starting at 4 or 6 weeks of age. (n=7/group).
Fig.4 Immunofluorescence staining of hPLA2R1 in the kidney. hPLA2R1(HO)/NPHS2-Cre+ mice showed sustained PLA2R1 expression.
Fig.5 Immunofluorescence staining of mIgG (green) and lamin A/C (red) in the kidney.
Overall, hPLA2R1-overexpressing mice exhibited increased IgG deposition in the kidney and primarily localized along the glomerular basement membrane.
Fig.6 Renal PSA staining and pathological analysis.
hPLA2R1-overexpressing mice exhibited evident kidney injury, including interstitial damage, tubular dilation, cast formation, and basement membrane thickening. (n=2/group/timepoint).
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