Knockout mouse model is a laboratory mouse in which researchers have inactivated, or "knocked out," an existing gene by deleting portions of the gene’s DNA sequence, or by replacing the gene with an altered DNA sequence. Knockout mice exhibit modifications in phenotype (observable traits) and thereby provide important clues about the function of individual genes. Mice and humans share many genes in common. Hence, information from knockout mouse models can shed light on the biological roles of specific genes as well as on the involvement of those genes in human disease.
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Strain Name：C57BL/6Smoc-Brs3em1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190608
Research Application：The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension.
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Strain Name：C57BL/6Smoc-Bscl2em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-2110535
Disease Connection：congenital generalized lipodystrophy type 2
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Strain Name：C57BL/6Smoc-Bsph1em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-205726
Research Application：secreted protein
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Strain Name：C57BL/6Smoc-Bspryem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-2104535
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Strain Name：C57BL/6Smoc-Bst1em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200057
Research Application：Therapeutic antibody target
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