NCI-N87-hCLDN18.2-Tg
Strain Information
Validation Data
Ⅰ.In vitro Expression of NCI-N87-hCLDN18.2 cell line
The hCLDN18.2 protein expression in the wild-type NCI-N87 and NCI-N87- hCLDN18.2 cells were measured by Flow Cytometry.
Figure 1. hCLDN18.2 expression in NCI-N87 and NCI-N87-hCLDN18.2 cell lines
Ⅱ.Characterization of in vivo growth kinetics
Cells were subcutaneously inoculated into the NMG mice.
Figure 2. Tumor growth curve of NCI-N87-hCLDN18.2 xenograft model (n=5)
Figure 3. Body weight change of NCI-N87-hCLDN18.2 xenograft model model (n=5)
Ⅲ.Expression of hCLDN18.2 protein in tumors
To verify the hCLDN18.2 protein expression, the tumors were dissected and separated for single cell suspension.
Figure 4. The expression of hCLDN18.2 in humanized modified tumors by FACS
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