MC38-hPD-L1/hCD47(2)

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Strain Information

Cell Line

MC38-Cd274em1(hCD274)SmocCd47em1(hCD47)Smoc

Cat. NO.

NM-S13-TM28

Model Description

The endogenous mouse Cd274/hCd47 gene was replaced by human CD274/hCD47 gene.

Strain State

Validation of tumorigenic capacity completed

Validation Data

image.pngFig1. hPD-L1 and hCD47 expression in vitro cultured cells of MC38-hPD-L1/hCD47.image.png

Fig2. In vivo validation of MC38-hPD-L1/hCD47 in C57BL/6 mice. C57BL/6 mice were inoculated with MC38-hPD-L1/hCD47 subcutaneously at 1×106 cells/mouse inoculum for tumor development.

image.pngFig3. hPD-L1 and hCD47 expression in tumors after in vivo growth of MC38-hPD-L1/hCD47 in wild type C57BL/6 mice. The tumors were collected at day 25 post tumor cell inoculation.



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