HLA-DPA1/HLA-DPB1
Nomenclature
C57BL/6Smoc-H2-Aatm1(HLA-DPA1*02:02)H2-Ab1tm1(HLA-DPB1*03:01)Smoc
Cat. NO.
NM-HU-234679
Strain State
Developing
Gene Summary
Gene Symbol
H2-Aa
Model Description
Validation Data
Fig.1 Detection of HLA-DPA1/HLA-DPB1 expression in large intestine and spleen by RT-PCR.
Wild type: one band at 278 bp with primers F4/R4(mH2-Aa) and one band at 123 bp with primers F/R(mGapdh);
Heterozygous: one band at 278 bp with primers F4/R4(mH2-Aa) and one band at 107 bp with primers F1/R1(hHLA-DPA1) and one band at 123 bp with primers F/R(mGapdh).
Abbr. M, DNA marker; HE, heterozygous; WT, wild type.
Fig.2 Detection of HLA-DPA1/HLA-DPB1 expression in large intestine and spleen by RT-PCR.
Wild type: one band at 299 bp with primers F3/R3(mH2-Ab1) and one band at 123 bp with primers F/R(mGapdh);
Heterozygous: one band at 299 bp with primers F3/R3(mH2-Ab1), one band at 113 bp with primers F2/R2(hHLA-DPB1) and one band at 123 bp with primers F/R(mGapdh).
Abbr. M, DNA marker; HE, heterozygous; WT, wild type.
Fig.3 Detection of MHC-Ⅱ expression on B cells and DCs in Peripheral blood in 13-week-old WT C57BL/6 and HE HLA-DPA1/HLA-DPB1 mice.
Fig.4 Detection of MHC-Ⅱ expression on B cells and DCs in Spleen in 13-week-old WT C57BL/6 and HE HLA-DPA1/HLA-DPB1 mice.
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