hFUS

Nomenclature

C57BL/6Smoc-Fustm1(hFUS)Smoc

Cat. NO.

NM-HU-233955

Strain State

Repository Live

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Gene Summary

Gene Symbol
Fus

Model Description

The endogenous mouse Fus gene was replaced by human FUS gene.

Validation Data

image.png

Fig.1 Detection of FUS expression in heart, spinal cord, kidney and brain of WT C57BL/6 and HO hFUS mice by RT-PCR (female, 7 weeks old). 

Wild type: only one band at 194 bp with primers F1/R1(mFus);

Homozygous: only one band at 320 bp with primers F2/R2(hFUS).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig.2 Detection of human FUS expression in WT C57BL/6 and HO hFUS mice by WB (female, 7 weeks old). 

Abbr. M, marker; WT, wild type; HO, Homozygous; PC, THP-1 cells.

Note. Arrow indicates expected molecular weight and asterisk indicates a nonspecific band.


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