hGPNMB

Nomenclature

C57BL/6Smoc-Gpnmbtm1(hGPNMB)Smoc

Cat. NO.

NM-HU-231635

Strain State

Repository Live

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Gene Summary

Gene Symbol
Gpnmb

Synonyms

ipd; Dchil; DC-HIL

NCBI ID

93695

MGI ID

1934765

Ensembl ID

ENSMUSG00000029816

Pubmed

Gpnmb

Human Ortholog

GPNMB

Model Description

The endogenous mouse Gpnmb gene was replaced by human GPNMB gene.

Validation Data

image.png

Fig.1 Detection of GPNMB expression in bladder of WT C57BL/6 mice (female, 8-10 weeks old) and hGPNMB knockin mice (female, 7 weeks old) by RT-PCR. 

Wild type: only one band at 186 bp with primers F1/R1(mGPNMB);

Homozygous: only one band at 139 bp with primers F2/R2(hGPNMB).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig.2 Detection of human GPNMB expression in WT C57BL/6 mice (male, 8-10 weeks old) and hGPNMB knockin mice (male, 14 weeks old) by WB. 

Abbr. M, marker; WT, wild type; HO, Homozygous; PC, positive control, B16F10 cells.

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