Arc-CreERT2

Nomenclature

C57BL/6Smoc-Arcem1(CreERT2-SV40-pA)Smoc

Cat. NO.

NM-KI-200101

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Arc

Synonyms

mArc; Arc3.1; C86064; arg3.1

NCBI ID

11838

MGI ID

88067

Ensembl ID

ENSMUSG00000022602

Pubmed

Arc

Human Ortholog

ARC

Model Description

A CreERT2 expression cassette was knocked into the Arc gene start codon site.
Research Application：By mating the reporter mice with CreERT2-expressing mice, Arc positive cells derived from double-positive mice were permanently labeled by fluorescent protein after tamoxifen treatment. Arc, a immediate-early gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites.

Validation Data

Arc-CreERT2-1.png

Fig.1  Detection of tdTomato (red) in the  brain of ArcCreERT2/+; Rosa26tdTomato/+  mouse after tamoxifen treatment. CreERT2-mediated recombination in the brain can be induced by tamoxifen. Some leakiness were detected in the hippocampus and thalamus prior to tamoxifen exposure.

Arc-CreERT2-2.png

Fig. 2 Detection of tdTomato (red) in various tissues of ArcCreERT2/+; Rosa26tdTomato/+ mice. CreERT2-mediated recombination in the brain, liver, kidney, pancreas, lung, stomach, submandibular gland, skin, testis and epididymis, pituitary gland and eye can be induced by tamoxifen. Some leakiness were detected in the brain and brown fat prior to tamoxifen exposure. (For more detailed information please contact our technical advisor.)

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