In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.
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Strain Name：C57BL/6JSmo-Tsc1tm1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-200231
Disease Connection：tuberous sclerosis, autism spectrum disorder, anterior segment dysgenesis
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Strain Name：C57BL/6JSmo-Tsc2tm1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-2102032
Disease Connection：uterine fibroid, tuberous sclerosis
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Strain Name：C57BL/6JSmo-Tsc22d3tm1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200055
Research Application：Diseases associated with TSC22D3 include Glucocorticoid-Induced Osteoporosis and Osteoporosis.
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