Fhit-KO
Nomenclature
C57BL/6JSmo-Fhitem1Smoc
Cat. NO.
NM-KO-190624
Strain State
Embryo cryopreservation
Gene Summary
Gene Symbol
Fhit
Model Description
Exon 4 of Fhit gene was deleted to generate Fhit knockout mice.
Research Application：The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage.
*Literature published using this strain should indicate: Fhit-KO mice (Cat. NO. NM-KO-190624) were purchased from Shanghai Model Organisms Center, Inc..
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