Knockout mouse model is a laboratory mouse in which researchers have inactivated, or "knocked out," an existing gene by deleting portions of the gene’s DNA sequence, or by replacing the gene with an altered DNA sequence. Knockout mice exhibit modifications in phenotype (observable traits) and thereby provide important clues about the function of individual genes. Mice and humans share many genes in common. Hence, information from knockout mouse models can shed light on the biological roles of specific genes as well as on the involvement of those genes in human disease.
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Strain Name：C57BL/6JSmo-Spg20em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-201074
Disease Connection：Troyer syndrome
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Strain Name：C57BL/6Smoc-Spg21em1Smoc
Strain State：Developing | Cat. NO.：TBD
Disease Connection：Mast syndrome
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Strain Name：C57BL/6JSmo-Spg7em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-201075
Disease Connection：hereditary spastic paraplegia 7
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Strain Name：C57BL/6JSmo-Sphk1em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-191035
Research Application：Immune system, inflammation, anti-apoptosis, TNF-α signaling and NF-κB activation pathway
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Strain Name：C57BL/6JSmo-Sphk2em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-191036
Research Application：Cell migration, proliferation and apoptosis; angiogenesis, tumorigenesis, cancer, breast cancer
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