Oprk1-2A-Cre

Nomenclature

C57BL/6Smoc-Oprk1em1(2A-Cre)Smoc

Cat. NO.

NM-KI-200299

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Oprk1

Synonyms

KOR; R21; KOR-1; MSL-1; Oprk2; K-OR-1

NCBI ID

18387

MGI ID

97439

Ensembl ID

ENSMUSG00000025905

Pubmed

Oprk1

Human Ortholog

OPRK1

Model Description

2A-Cre expression cassette was knocked into the Oprk1 gene stop codon site. Oprk1 (opioid receptor, kappa 1) encodes opioid receptor which was expressed in multiple brain regions. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids.
Research Application：Cre recombinase tool; Neuroscience

Validation Data

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Fig. 1 Cre-mediated recombination in the brain of Oprk1Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the brain of Oprk1Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Detection of tdTomato(red) in various tissues of Oprk1Cre/+; Rosa26tdTomato/+ mice. Tdtomato was also expressed in some cells of the liver, stomach, intestine, colon, muscle, eyes, heart, spleen and lung. Tdtomato expression can not be observed in the salivary gland, brown fat and skin.(For more detailed information please contact our technical advisor.)


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