In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.
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Strain Name：C57BL/6JSmo-Gja1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200180
Disease Connection：oculodentodigital dysplasia
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Strain Name：C57BL/6Smoc-Gjb1em1(flox)Smoc
Strain State：Developing | Cat. NO.：NM-CKO-260784
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Strain Name：C57BL/6JSmo-Gjb2em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-210062
Disease Connection：autosomal recessive nonsyndromic deafness 1A, autosomal dominant keratitis-ichthyosis-deafness syndrome
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