In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.
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Strain Name：C57BL/6Smoc-Gfpt1em1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD
Disease Connection：congenital myasthenic syndrome 12
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Strain Name：C57BL/6JSmo-Gfra1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-232181
Disease Connection：Hirschsprung's disease
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Strain Name：C57BL/6JSmo-Gfra2em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-241948
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Strain Name：C57BL/6JSmo-Gfra4em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-232182
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