hTDP43-A315T

Nomenclature

C57BL/6Smoc-Tgtn(pPrp-hTDP-43 A315T)1Smoc

Cat. NO.

NM-KI-234659

Strain State

Repository Live

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Model Description

The pPrp-hTDP-43 A315T expression cassette was knocked into the Chr9 locus.

Validation Data

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Fig.1 TDP43 mRNA sequencing in hTDP43-A315T mice. Sequencing data of RT-PCR products confirmed the presence of the target mutation in hTDP43-A315T mice.  (Female, 3 weeks old)

Abbr. HE, heterozygous; WT, wild type.

image.png

Fig.2 Detection of human TDP43 expression in hTDP43-A315T mice by WB. Tissues lysates were collected from spinal cord and brain of wild-type C57BL/6 mice (female, 3 weeks old) and heterozygous hTDP43-A315T mice (female, 3 weeks old), and then analyzed by western blot with anti-TDP43 antibody (abnova, H00023435-M01). 20 μg of total proteins were loaded for western blotting analysis.


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