C57BL/6

1. Spatially Defined DNA Origami Cell Engagers for T and Natural Killer Cell-Mediated Immune Modulation
Published year：2026 References：ACS Nano

2. A novel whole cancer cell vaccine based on modified β-glucan elicits robust anti-tumor immunity
Published year：2026 References：Theranostics

3. 3D-cultured hUC-MSC-derived exosomes as macrophage mediators to suppress cholestatic fibrosis in mice via miR-1291–mediated multi-targeted pathways
Published year：2026 References：CHEMICAL ENGINEERING JOURNAL

4. Targeting senescent EGR1+ B cells enhances immunotherapy efficacy in esophageal squamous cell carcinoma
Published year：2026 References：Cell Reports Medicine

5. Ganoderma lucidum polysaccharide ameliorates cancer cachexia with enhanced efficacy in aged group by reprogramming arginine metabolism to modulate Treg formation
Published year：2026 References：CANCER LETTERS

6. Post-traumatic stress disorder impairs CD8+ T cell-dependent anti-tumor immune responses by downregulating thiamine
Published year：2026 References：Cell Communication and Signaling

7. Long-term sucralose exposure accelerates ovarian aging via gut microbiota dysbiosis
Published year：2026 References：npj Science of Food

8. Law-NQO1 redox boosts the pentose phosphate pathway to confer stem-like properties and antitumor durability in effector CD8+ T cells
Published year：2026 References：Cell Chemical Biology

9. Glioma Cell Membrane–Coated CaCO3 Nanoparticles for Localized Postoperative Chemo–Calcium Overload Therapy to Prevent Glioma Recurrence
Published year：2026 References：International Journal of Nanomedicine

10. Exposure to paraben in early gestational period: Impact on placental estrogen biosynthesis and fetal growth restriction
Published year：2026 References：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

11. NOTCH3 attenuates cytotoxicity via RBPJ-dependent PVR upregulation to influence immunotherapy outcomes in colorectal cancer
Published year：2026 References：Frontiers in Immunology

12. Botulinum Neurotoxin Type A1 Alleviates Bleomycin-induced Skin Fibrosis by Inhibiting PI3K-Akt Pathway and Associated Cell Cycle and Proliferation
Published year：2026 References：JOURNAL OF INVESTIGATIVE DERMATOLOGY

13. Eupalinolide B ameliorates liver fibrosis by targeting PKCα to suppress the AKT/mTOR axis in hepatic stellate cells
Published year：2026 References：JOURNAL OF ETHNOPHARMACOLOGY

14. GABA induces myokine irisin release from skeletal muscle
Published year：2026 References：LIFE SCIENCES

15. ROS-responsive diselenide exosomes restores mitophagy to resolve sterile inflammation in liver IRI
Published year：2026 References：EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

16. ACSL4 Inhibition by AS-252424 Protects Visual Function by Suppressing RGC Ferroptosis After Retinal Ischemia Reperfusion Injury
Published year：2026 References：MOLECULAR NEUROBIOLOGY

17. Transcriptional Heterogeneity of Cardiac Remodeling Between Type 1 and Type 2 Diabetes
Published year：2026 References：Biomedicines

18. Lycium barbarum Polysaccharide Alleviates Renal Damage in Mouse Sepsis by Regulating M1/M2 Macrophage Polarization
Published year：2026 References：Food Science & Nutrition

19. Phenothiazine alleviates cisplatin-mediated acute kidney injury by inhibiting ferroptosis
Published year：2026 References：CELL AND TISSUE RESEARCH

20. Loss of hepaCAM inhibits cholesterol biosynthesis and impairs learning and memory in mice
Published year：2026 References：BRAIN RESEARCH

21. Pyruvate kinase M2 -mediated histone lactylation alters three-dimensional genomic architecture in polycystic ovary syndrome
Published year：2025 References：Signal Transduction and Targeted Therapy

22. Combinatorial tagging generates a multi-purpose knock-in mouse model revealing phase separation-dependent germ granules in RNA homeostasis and germline development
Published year：2025 References：CELL DEATH AND DIFFERENTIATION

23. Inhibiting Liver-Derived C3 Protein Rescues Anesthesia/Surgery-Induced Cognitive Impairment, Synaptic Disorders, and Microglial Phagocytosis
Published year：2025 References：Advanced Science

24. High-Resolution Multiplexed Sequencing of Single-Cell Full-length Transcriptome Via Combinational Barcoded Tn5 Transposon Insertion
Published year：2025 References：Advanced Science

25. SMC4 Promotes Prostate Cancer Cell Proliferation and Metastasis via the Rheb/mTOR Pathway
Published year：2025 References：Advanced Science

26. Reversible acetylation of ribosomal protein S1 serves as a smart switch for Salmonella to rapidly adapt to host stress
Published year：2025 References：NUCLEIC ACIDS RESEARCH

27. Glycyrrhiza polysaccharide-adjuvanted liposomal vaccine potentiates tumor immunotherapy through lymph node-targeted modulation of the DC-T cell axis
Published year：2025 References：JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

28. Sustained mTORC1 activation in activated T cells impairs vaccine responses in older individuals
Published year：2025 References：Science Advances

29. Targeting the ac4C ‘Writer’ NAT10 enhances pancreatic cancer immunotherapy via dual modulation of CD8+ T cells and tumor cells
Published year：2025 References：Cell Death & Disease

30. Extracellular vesicles for delivery of functional telomerase
Published year：2025 References：Cell Communication and Signaling

31. An injectable cisplatin hydrogel effectively suppresses tumors while preserving anti-infective immunity
Published year：2025 References：MATERIALS & DESIGN

32. The Artemisia argyi oil reduces high-fat diet-induced obesity by enhancing thermogenesis in brown adipose tissue
Published year：2025 References：npj Science of Food

33. Cancer-associated adipocytes mediate CD8+T cell dysfunction via FGF21-driven lipolysis
Published year：2025 References：Cell Reports

34. Activated T cells degrade extracellular proteins to enhance effector functions
Published year：2025 References：Cell Reports

35. Therapeutic efficacy of Sanhuang Xiexin decoction on atopic dermatitis via suppressing STAT3 signaling
Published year：2025 References：JOURNAL OF ETHNOPHARMACOLOGY

36. Sex-dimorphic reprogramming of fetal mouse brain development by maternal estradiol excess
Published year：2025 References：Biology of Sex Differences

37. Therapeutic Efficacy and Mechanistic Insights of Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in Chemotherapy-Induced Oral Mucositis
Published year：2025 References：JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

38. α-Klotho Supplementation Mitigates Cumulative Exercise-Induced Fatigue via Coordinated NRF2-Mediated Antioxidant Defense and AKT/GS-Driven Hepatic Glycogen Supercompensation in Mice
Published year：2025 References：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

39. Integrating global burden of disease analysis and single-cell omics identifies ANTXR2 as a potential diagnostic biomarker for AML in China
Published year：2025 References：INTERNATIONAL IMMUNOPHARMACOLOGY

40. Andrographolide inhibits the upregulation of SLC19A3 to block the adipogenic differentiation of adipose-derived stem cells
Published year：2025 References：iScience

41. Optimization of thrombopoietin mimetic peptide fusion proteins with albumin-binding domain for enhanced bioactivity and extended half-life
Published year：2025 References：Scientific Reports

42. Hepatic stellate cells shape the ECM-disorganized and immunosuppressive microenvironment via CCL11/CCR3 axis in lenvatinib-treated hepatocellular carcinoma
Published year：2025 References：CELLULAR SIGNALLING

43. Blockade of CD47 signaling improves ferroptosis of lung cancer cells via activating Nrf2/FPN signaling
Published year：2025 References：CELLULAR SIGNALLING

44. Optical characterization of ocular collagen microstructure and anisotropy in animal and human eyes
Published year：2025 References：Biomedical Optics Express

45. Asiaticoside protects against PDF-induced peritoneal fibrosis via suppression of AhR/Nrf2-mediated MMT and oxidative stress
Published year：2025 References：NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

46. A multi-omics landscape of programmed cell death in acetaminophen-induced acute kidney injury
Published year：2025 References：RENAL FAILURE

47. USP18 promote tumor immune evasion in pancreatic cancer through enhancing autolysosome-mediated degradation of MHC-I
Published year：2025 References：American Journal of Cancer Research

48. Helicobacter pylori Lipopolysaccharide Upregulates MDM2 via the TLR4/MAPK/AP-1 Pathway to Promote Gastric Cancer Progression
Published year：2025 References：DIGESTIVE DISEASES AND SCIENCES

49. Protocol for co-culture of primary neurons and organotypic hippocampal brain slices from mice
Published year：2025 References：STAR Protocols

50. Lighting up arginine metabolism reveals its functional diversity in physiology and pathology
Published year：2024 References：Cell Metabolism

51. 2D Differential Metallic Immunopotentiators Drive High Diversity and Capability of Antigen-specific Immunity Against Tumor
Published year：2024 References：Advanced Science

52. Drug evaluation platform based on non-destructive and real-time in situ organoid fate state monitoring by graphene field-effect transistor
Published year：2024 References：CHEMICAL ENGINEERING JOURNAL

53. A spatiotemporal transcriptomic atlas of mouse placentation
Published year：2024 References：Cell Discovery

54. TIPE2 protein restrains invariant NKT activation and protects against immune-mediated hepatitis in mice
Published year：2024 References：HEPATOLOGY

55. Extending dual-targeting upper-limit in liposomal delivery of lithospermic acid B for Alzheimer's mitochondrial revitalization
Published year：2024 References：JOURNAL OF CONTROLLED RELEASE

56. PPARα suppresses growth of hepatocellular carcinoma in a high-fat diet context by reducing neutrophil extracellular traps release
Published year：2024 References：JHEP Reports

57. Microglia LILRB4 upregulation reduces brain damage after acute ischemic stroke by limiting CD8+ T cell recruitment
Published year：2024 References：Journal of Neuroinflammation

58. Advanced paternal age exacerbates neuroinflammation in offspring via m6A modification-mediated intergenerational inheritance
Published year：2024 References：Journal of Neuroinflammation

59. Absence of Langerhans cells resulted in over-influx of neutrophils and increased bacterial burden in skin wounds
Published year：2024 References：Cell Death & Disease

60. Osteocalcin-expressing neutrophils from skull bone marrow exert immunosuppressive and neuroprotective effects after TBI
Published year：2024 References：Cell Reports

61. SSRI antidepressant citalopram reverses the Warburg effect to inhibit hepatocellular carcinoma by directly targeting GLUT1
Published year：2024 References：Cell Reports

62. IGSF9 promotes tumor invasion and metastasis through GSK-3β/β-catenin mediated EMT in lung cancer
Published year：2024 References：NEOPLASIA

63. MRG15 promotes cell apoptosis through inhibition of mitophagy in hyperlipidemic acute pancreatitis
Published year：2024 References：APOPTOSIS

64. HMGB2 promotes smooth muscle cell proliferation through PPAR-γ/PGC-1α pathway-mediated glucose changes in aortic dissection
Published year：2024 References：ATHEROSCLEROSIS

65. Betaine alleviates nonalcoholic fatty liver disease (NAFLD) via a manner involving BHMT/FTO/m6A/ PGC1α signaling
Published year：2024 References：JOURNAL OF NUTRITIONAL BIOCHEMISTRY

66. The natural flavonoid pinocembrin shows antithrombotic activity and suppresses septic thrombosis
Published year：2024 References：INTERNATIONAL IMMUNOPHARMACOLOGY

67. F-Box and WD repeat domain containing 7 induces infectious osteomyelitis by regulating MYB stability and ubiquitination
Published year：2024 References：SCANDINAVIAN JOURNAL OF IMMUNOLOGY

68. Full-length circRNA sequencing method using low-input RNAs and profiling of circRNAs in MPTP-PD mice on a nanopore platform
Published year：2024 References：ANALYST

69. SIRT5 safeguards against T-2 toxin induced liver injury by repressing iron accumulation, oxidative stress, and the activation of NLRP3 inflammasome
Published year：2024 References：TOXICOLOGY AND APPLIED PHARMACOLOGY

70. Docosahexaenoic acid insufficiency impairs placental angiogenesis by repressing the methylene-bridge fatty acylation of AKT in preeclampsia
Published year：2024 References：PLACENTA

71. Neuron-specific deficiency of autophagy increases neuronal loss in traumatic brain injury
Published year：2024 References：PNAS Nexus

72. Establishment of a Mouse Model for Porokeratosis Due to Mevalonate Diphosphate Decarboxylase Deficiency
Published year：2024 References：SKIN RESEARCH AND TECHNOLOGY

73. Identification of Periosteal Osteogenic Progenitors in Jawbone
Published year：2022 References：JOURNAL OF DENTAL RESEARCH

74. Analysis of Mononuclear Phagocytes Disclosed the Establishment Processes of Two Macrophage Subsets in the Adult Murine Kidney
Published year：2022 References：Frontiers in Immunology

75. Prussian Blue Scavenger Ameliorates Hepatic Ischemia-Reperfusion Injury by Inhibiting Inflammation and Reducing Oxidative Stress
Published year：2022 References：Frontiers in Immunology

76. Gynostemma pentaphyllum polysaccharides ameliorate non-alcoholic steatohepatitis in mice associated with gut microbiota and the TLR2/NLRP3 pathway
Published year：2022 References：Frontiers in Endocrinology

77. Small RNA perspective of physical exercise-related improvement of male reproductive dysfunction due to obesity
Published year：2022 References：Frontiers in Endocrinology

78. Bie-Jia-Ruan-Mai-Tang, a Chinese Medicine Formula, Inhibits Retinal Neovascularization in Diabetic Mice Through Inducing the Apoptosis of Retinal Vascular Endothelial Cells.
Published year：2022 References：Frontiers in Cardiovascular Medicine

79. Protein arginine methyltransferase 3 inhibits renal tubulointerstitial fibrosis through asymmetric dimethylarginine
Published year：2022 References：Frontiers in Medicine

80. Identification of novel key genes and potential candidate small molecule drugs in diabetic kidney disease using comprehensive bioinformatics analysis
Published year：2022 References：Frontiers in Genetics

81. Identification of circular RNA biomarkers for Pien Tze Huang treatment of CCl4‑induced liver fibrosis using RNA‑sequencing
Published year：2022 References：Molecular Medicine Reports

82. Sodium Tanshinone IIA Sulfonate Improves Adverse Ventricular Remodeling Post-MI by Reducing Myocardial Necrosis, Modulating Inflammation, and Promoting Angiogenesis
Published year：2022 References：CURRENT PHARMACEUTICAL DESIGN

83. M351-0056 is a novel low MW compound modulating the actions of the immune-checkpoint protein VISTA
Published year：2021 References：BRITISH JOURNAL OF PHARMACOLOGY

84. Ablation of Survivin in T Cells Attenuates Acute Allograft Rejection after Murine Heterotopic Heart Transplantation by Inducing Apoptosis
Published year：2021 References：Frontiers in Immunology

85. Methyl Diet Enhanced Sepsis-Induced Mortality Through Altering Gut Microbiota
Published year：2021 References：Journal of Inflammation Research

86. Depletion of gut microbiota induces skeletal muscle atrophy by FXR-FGF15/19 signalling
Published year：2021 References：ANNALS OF MEDICINE

87. Comprehensive Bioinformatics Analysis Identifies POLR2I as a Key Gene in the Pathogenesis of Hypertensive Nephropathy
Published year：2021 References：Frontiers in Genetics

88. Effect of κ-carrageenan on glucolipid metabolism and gut microbiota in high-fat diet-fed mice
Published year：2021 References：Journal of Functional Foods

89. The enrichment of neutrophil extracellular traps impair the placentas of systemic lupus erythematosus through accumulating decidual NK cells
Published year：2021 References：Scientific Reports

90. Knockdown of VDAC1 alleviates the cognitive dysfunction secondary to sepsis-associated encephalopathy
Published year：2021 References：American Journal of Translational Research

91. Activation of Gonadotropin-releasing Hormone Receptor Impedes the Immunosuppressive Activity of Decidual Regulatory T Cells via Deactivating the Mechanistic Target of Rapamycin Signaling
Published year：2021 References：IMMUNOLOGICAL INVESTIGATIONS

92. Brain-derived neurotrophic factor attenuates cognitive impairment and motor deficits in a mouse model of Parkinson's disease
Published year：2021 References：Brain and Behavior

93. miR-31 promotes neural stem cell proliferation and restores motor function after spinal cord injury
Published year：2021 References：EXPERIMENTAL BIOLOGY AND MEDICINE

94. Autophagy-lysosome inhibitor chloroquine prevents CTLA-4 degradation of T cells and attenuates acute rejection in murine skin and heart transplantation
Published year：2020 References：Theranostics

95. The triterpenoid sapogenin (2α-OH-Protopanoxadiol) ameliorates metabolic syndrome via the intestinal FXR/GLP-1 axis through gut microbiota remodelling
Published year：2020 References：Cell Death & Disease

96. An electrochemical sensor for bacterial lipopolysaccharide detection based on dual functional Cu2+-modified metal–organic framework nanoparticles
Published year：2020 References：MICROCHIMICA ACTA

97. Salmonella and S. aureus Escape From the Clearance of Macrophages via Controlling TFEB
Published year：2020 References：Frontiers in Microbiology

98. MiR-1-3p regulates the differentiation of mesenchymal stem cells to prevent osteoporosis by targeting secreted frizzled-related protein 1
Published year：2020 References：BONE

99. A Brain Signaling Framework for Stress-Induced Depression and Ketamine Treatment Elucidated by Phosphoproteomics
Published year：2020 References：Frontiers in Cellular Neuroscience

100. Fisetin regulates gut microbiota to decrease CCR9+/CXCR3+/CD4+ T-lymphocyte count and IL-12 secretion to alleviate premature ovarian failure in mice
Published year：2020 References：American Journal of Translational Research

101. Extracellular ubiquitin promotes hepatoma metastasis by mediating M2 macrophage polarization via the activation of the CXCR4/ERK signaling pathway
Published year：2020 References：Annals of Translational Medicine

102. Emodin ameliorates tubulointerstitial fibrosis in obstructed kidneys by inhibiting EZH2
Published year：2020 References：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

103. miR-34a attenuates myocardial fibrosis in diabetic cardiomyopathy mice via targeting Pin-1
Published year：2020 References：CELL BIOLOGY INTERNATIONAL

104. Linc-FOXD3 knockdown enhances hippocampal NSCs activation through upregulation of the Wnt/β-catenin pathway
Published year：2020 References：NEUROSCIENCE LETTERS

105. The effect of Tauroursodeoxycholic acid (TUDCA) and gut microbiota on murine gallbladder stone formation
Published year：2020 References：Annals of Hepatology

106. Exercise Preconditioning Protects against Acute Cardiac Injury Induced by Lipopolysaccharide Through General Control Nonderepressible 2 Kinase
Published year：2020 References：International Heart Journal

107. MRG15 orchestrates rhythmic epigenomic remodelling and controls hepatic lipid metabolism
Published year：2020 References：Nature Metabolism

108. Pravastatin regulates host foreign-body reaction to polyetheretherketone implants via miR-29ab1-mediated SLIT3 upregulation
Published year：2019 References：BIOMATERIALS

109. miR-146a attenuates apoptosis and modulates autophagy by targeting TAF9b/P53 pathway in doxorubicin-induced cardiotoxicity
Published year：2019 References：Cell Death & Disease

110. Longevity Effect of Liuwei Dihuang in Both Caenorhabditis Elegans and Aged Mice
Published year：2019 References：Aging and Disease

111. P11 Loss-of-Function is Associated with Decreased Cell Proliferation and Neurobehavioral Disorders in Mice
Published year：2019 References：International Journal of Biological Sciences

112. Stimulation of histamine H4 receptor participates in cold-induced browning of subcutaneous white adipose tissue
Published year：2019 References：AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

113. Herbs-partitioned moxibustion improves intestinal epithelial tight junctions by upregulating A20 expression in a mouse model of Crohn’s disease
Published year：2019 References：BIOMEDICINE & PHARMACOTHERAPY

114. Inhibition of SIRT1 promotes taste bud stem cell survival and mitigates radiation-induced oral mucositis in mice
Published year：2019 References：American Journal of Translational Research

115. OPG is Required for the Postnatal Maintenance of Condylar Cartilage
Published year：2019 References：CALCIFIED TISSUE INTERNATIONAL

116. Decreased cpg15 augments oxidative stress in sleep deprived mouse brain
Published year：2019 References：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

117. Alcohol and HBV synergistically promote hepatic steatosis
Published year：2019 References：Annals of Hepatology

118. Effects of farnesoid-X-receptor SUMOylation mutation on myocardial ischemia/reperfusion injury in mice
Published year：2018 References：EXPERIMENTAL CELL RESEARCH

119. Nerve growth factor metabolic dysfunction contributes to sevoflurane-induced cholinergic degeneration and cognitive impairments
Published year：2018 References：BRAIN RESEARCH

120. Regulation of the NLRP3 inflammasome and macrophage pyroptosis by the p38 MAPK signaling pathway in a mouse model of acute lung injury
Published year：2018 References：Molecular Medicine Reports

121. Berberine attenuate staphylococcal enterotoxin B-mediated acute liver injury via regulating HDAC expression
Published year：2018 References：AMB Express

122. Contradictory effects of mitochondria- and non-mitochondria-targeted antioxidants on hepatocarcinogenesis by altering DNA repair in mice
Published year：2017 References：HEPATOLOGY

123. RNAi targeting Nogo Receptor enhanced survival and proliferation of murine retinal ganglion cells during N-methyl-D-aspartate-induced optic nerve crush
Published year：2017 References：Oncotarget

124. Depletion of circulating monocytes suppresses IL-17 and HMGB1 expression in mice with LPS-induced acute lung injury
Published year：2017 References：AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

125. SIRT3 prevents angiotensin II-induced renal tubular epithelial-mesenchymal transition by ameliorating oxidative stress and mitochondrial dysfunction
Published year：2017 References：MOLECULAR AND CELLULAR ENDOCRINOLOGY

126. Knockout of BRD7 results in impaired spermatogenesis and male infertility.
Published year：2016 References：Scientific Reports

127. NMNAT3 is involved in the protective effect of SIRT3 in Ang II-induced cardiac hypertrophy
Published year：2016 References：EXPERIMENTAL CELL RESEARCH

128. TDRP deficiency contributes to low sperm motility and is a potential risk factor for male infertility
Published year：2016 References：American Journal of Translational Research

129. Medium-chain triglycerides promote macrophage reverse cholesterol transport and improve atherosclerosis in ApoE-deficient mice fed a high-fat diet
Published year：2016 References：NUTRITION RESEARCH

130. Hepatitis B surface antigen (HBsAg) and core antigen (HBcAg) combine CpG oligodeoxynucletides as a novel therapeutic vaccine for chronic hepatitis B infection
Published year：2015 References：VACCINE

131. Effects of Dendritic Cells from Hepatitis B Virus Transgenic Mice-Stimulated Autologous Lymphocytes on Hepatitis B Virus Replication: A Study on the Impact of Specific Sensitized Effector Cells on In Vitro Virus Replication
Published year：2015 References：VIRAL IMMUNOLOGY

132. Cytotoxic T lymphocyte antigen 4 decreases humoral and cellular immunity by adenovirus to enhance target GFP gene transfer in C57BL/6 mice
Published year：2015 References：IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

133. Establishment of a transgenic mouse model of corneal dystrophy overexpressing human BIGH3
Published year：2013 References：INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

134. An essential role for DNA methyltransferase 3a in melanoma tumorigenesis
Published year：2009 References：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS