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Models

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Mice

hCD28

Strain Name:C57BL/6Smoc-Cd28tm2(hCD28)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-190011
Validation Data:Presence

The endogenous mouse Cd28 gene was replaced by human CD28 gene.

Mice

Abcb4-KO(FVB)

Strain Name:FVB-Abcb4em1Smoc
Strain State:Repository Live | Cat. NO.:NM-KO-200584
Validation Data:Presence

Exon 3-4 of Abcb4 gene was deleted to generate Abcb4 knockout mice.

Mice

hC5

Strain Name:C57BL/6Smoc-Hctm1(hC5)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-2000013
Validation Data:Presence

The endogenous mouse C5a gene was replaced by human C5 gene.

Mice

Rag2/IL2rg-KO/hVEGFR2

Strain Name:C57BL/6Smoc-Il2rgem1Rag2em1Kdrtm2(hKDR)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-220087

IL2rg-KO (NM-KO-210098) mice were crossed with Rag2-KO/hKDR (NM-HU-200280) mice to generate Rag2/IL2rg-KO/hKDR mouse models.

Mice

hHBB

Strain Name:C57BL/6Smoc-Hbb-bt&Hbb-bstm1(hHBB)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-2000080
Validation Data:Presence

The endogenous mouse Hbb-bt and Hbb-bs gene was replaced by human HBB gene.

Mice

hC3

Strain Name:C57BL/6Smoc-C3tm1(hC3)/Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-2000079
Validation Data:Presence

The endogenous mouse C3 gene was replaced by human C3 gene.

Mice

hCCR1

Strain Name:C57BL/6Smoc-Ccr1tm3(hCCR1)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-190067

The endogenous mouse Ccr1 gene was replaced by human CCR1 gene.

Mice

Mefv-hMEFV*V726A

Strain Name:C57BL/6Smoc-Mefvtm1(hMEFV-V726A)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-KI-200221

Exon 7-10 of the endogenous mouse Mefv gene was replaced by human mutation gene (exon7-10).

Mice

Ace2-2A-CreERT2

Strain Name:C57BL/6Smoc-Ace2em2(2A-CreERT2-WPRE-polyA)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-KI-200187
Validation Data:Presence

A 2A-CreERT2-WPRE-polyA expression cassette was knocked into the Ace2 gene stop codon site. Ace2 encodes angiotensin I converting enzyme 2. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Cre. This strain is useful for studying lung injury and kidney disease caused by SARS coronavirus infection.

Mice

B2m-KO(NMG)

Strain Name:M-NSG-B2memSmoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-NSG-002
Validation Data:Presence

This B2m knockout mouse model was obtained by knocking out the exon 2-3 region of mouse B2m gene on the background of NMG mouse.

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