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Models

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Mice

H11-CAG-LSL-Myc

Strain Name：C57BL/6Smoc-Igs2em1(CAG-LSL-Myc)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00039
Validation Data：Presence

The c-Myc gene (also known as Myc) is abnormally expressed in many tumors and plays a critical role in the regulation of cell proliferation, growth and metabolism, gene instability, stimulation of angiogenesis, malignant transformation, cell differentiation and apoptosis. These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Myc oncogene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination. Myc is expressed when bred to mice that express Cre recombinase.

Mice

R26-CAG-LSL-hACE2-IRES-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-FRT-2xpolyA-CAG-FRT-Loxp-stop-loxp-human ACE2-IRES-tdTomato-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200188
Validation Data：Presence

These mice harbor a SA-FRT-2xpolyA-CAG-FRT-Loxp-stop-loxp-human ACE2-IRES-tdTomato-WPRE-polyAA cassette in the Rosa26 locus generated by homologous recombination.

Mice

hCTLA-4

Strain Name：C57BL/6Smoc-Ctla4em1(hCTLA4) Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00014
Validation Data：Presence

The endogenous mouse Ctal4 gene was replaced by human CTLA4 gene. While hCTLA4(2)(Stock No.NM-HU-190038) mice function similarly to hCTLA4 mice,for more detailed information please contact our technical advisor.

Mice

Lgr5-EGFP-IRES-CreERT2

Strain Name：C57BL/6Smoc-Lgr5em1(EGFP-IRES-creERT2-WPRE-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200154
Validation Data：Presence

A EGFP-IRES-creERT2-WPRE-polyA expression cassette was knocked into the Lgr5 gene start codon site.

Mice

Braf-Flox

Strain Name：C57BL/6Smoc-Brafem1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200073

These mice carry loxP sites flanking exon 5 of Braf gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Braf gene.

Mice

hC5

Strain Name：C57BL/6Smoc-Hcem1(hC5)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000013
Validation Data：Presence

The endogenous mouse C5a gene was replaced by human C5 gene.

Mice

hAPOC3

Strain Name：C57BL/6Smoc-Apoc3em1(hAPOC3)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-225050
Validation Data：Presence

The endogenous mouse Apoc3 gene was replaced by human APOC3 gene.

Mice

A1bg-Flox

Strain Name：C57BL/6Smoc-A1bgem1(flox)Smoc
Strain State：Developing | Cat. NO.：NM-CKO-253740

These mice carry loxP sites flanking exon 1-5 of A1bg gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of A1bg gene.

Mice

hCD40

Strain Name：C57BL/6Smoc-Cd40em1(hCD40) Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00076
Validation Data：Presence

The endogenous extracellular mouse Cd40 gene was replaced by the extracellular region of human CD40 gene.

Mice

A2m-Flox

Strain Name：C57BL/6Smoc-A2mem1(flox)Smoc
Strain State：Developing | Cat. NO.：NM-CKO-253744

These mice carry loxP sites flanking exon 2-4 of A2m gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of A2m gene.

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