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U-GEMMs

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Mice

Rag2-KO/hVEGFR2

Strain Name：C57BL/6Smoc-Kdrtm2(hKDR)Rag2em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200280

The Rag2 gene of NM-HU-00098 was knock out.

Mice

Rag2-KO

Strain Name：C57BL/6Smoc-Rag2em2Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190429

Partial exon 3 of Rag2 gene was deleted to generate Rag2 knockout mice. Deletion of this region will cause frameshift and result in loss of function of mouse Rag2 gene.

Mice

hABCC2

Strain Name：C57BL/6Smoc-Abcc2tm1(hABCC2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200254

The endogenous mice Abcc2 gene was replaced by human ABCC2 gene.

Mice

hCCL1

Strain Name：C57BL/6Smoc-Ccl1em2(hCCL1)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000074

The endogenous mouse Ccl1 gene was replaced by human CCL1 gene.

Mice

Mefv-hMEFV*V726A

Strain Name：C57BL/6Smoc-Mefvem1(hMEFV-V726A)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200221

Exon 7-10 of the endogenous mouse Mefv gene was replaced by human mutation gene (exon7-10).

Mice

h4-1BB(2)/hOX40

Strain Name：C57BL/6Smoc-Tnfrsf9tm2(TNFRSF9)Tnfrsf4em1(hTNFRSF4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200272

hTNFRSF9(NM-HU-190077) was crossed with hOX40(NM-HU-00041)to generate h4-1BB(2)/hOX40 mice

Mice

hCTLA-4

Strain Name：C57BL/6Smoc-Ctla4em1(hCTLA4) Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00014

The endogenous mouse Ctal4 gene was replaced by human CTLA4 gene. While hCTLA4(2)(Stock No.NM-HU-190038) mice function similarly to hCTLA4 mice,for more detailed information please contact our technical advisor.

Mice

Rag2-KO(Rag2-EGFP)

Strain Name：B6;129S-Rag2tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00070

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag2 gene start codon site. As a Rag2 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag2 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

CAG-LSL-dCas9-SPH-Tg

Strain Name：C57BL/6Smoc-Tg(CAG-LSL-dCas9-SPH)Smoc
Strain State：Repository Live | Cat. NO.：NM-TG-00025

Cre-dependent SunTag-p65-HSF1 (SPH) transgenic mice were generated with piggyBac transposon system in F1 zygotes and crossed with wild type C57BL/6 mice., SPH transgenic mouse containing HA-tagged dCas9 fused with 10xGCN4, which is linked with p65-HSF1 and EGFP in tandem via P2A and T2A respectively. The transgene is driven by the ubiquitous CAG promoter and interrupted by a loxP-stop-loxP (LSL) cassette to render Cas9 expression inducible by the Cre recombinase. Expression of dCas9 can be detected using primary antibody: rabbit monoclonal antibody to HA-tag (1:1000, #3724, CST45) and secondary antibody: goat anti-rabbit Alexa Fluor 488 (1:1000, #A-11034, Thermo Fisher).

Mice

hTIM3

Strain Name：C57BL/6Smoc-Havcr2em1(hHAVCR2)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00054

The endogenous mouse Tim3 gene was replaced by human TIM3 gene .

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