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U-GEMMs

About 42,431 results
Mice

hCD3EDG(BALB/c)

Strain Name：BALB/c-Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)/CbSmoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220122

The endogenous mouse Cd3e/Cd3d/Cd3g genes were replaced by human CD3E/CD3D/CD3G gene.

Mice

hIL6/hIL6R

Strain Name：C57BL/6Smoc-Il6tm1(hIL6)Il6raem1(hIL6R)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190025

This IL6 and IL6R double knockin strain is established by crossing IL6-HU and IL6R-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hCD40/hPD-1/hPD-L1

Strain Name：C57BL/6Smoc-Cd40em1(hCD40)Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210406

hPD-1/hPD-L1(NM-HU-00100) was crossed with hCD40（NM-HU-00076）to generate hCD40/hPD-1/hPD-L1 mice

Mice

Il1a-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il1aem1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00009

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon. According to this strategy, the endogenous Il1a expression is supposed to be eliminated and the intrisic promoter drives the expression of reporter genes, which reflexs the activity of Il1a.

Mice

hIl5

Strain Name：C57BL/6Smoc-Il5tm3(hIL5)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190001

This IL5 humanized mouse model was established by replacing the mouse Il5 gene coding exons and introns with the human TLR9 corresponding sequence by homologous recombination.

Mice

hIL1RL1

Strain Name：C57BL/6Smoc-Il1rl1tm4(hIL1RL1)/Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-2000067

The endogenous mouse Il1rl1 gene was replaced by human IL1RL1 gene.

Mice

Il15-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il15em1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00027

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il15.

Mice

Eno2-2A-CreERT2

Strain Name：C57BL/6Smoc-Eno2em1(2A-CreERT2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200011

A 2A-CreERT2 expression cassette was knocked into the Eno2 gene stop codon site.

Mice

Slc6a1-S295L

Strain Name：C57BL/6Smoc-Slc6a1em2(S295L)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190014

These mice carry a p.S295L mutation in Slc6a1 gene .

Mice

hHLA-A11

Strain Name：C57BL/6Smoc-H2-K1tm1(hHLA-A11)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-204987

The endogenous mice H2-K1 gene was replaced by human HLA-A11 gene.

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