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U-GEMMs

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Mice

hB7H3

Strain Name：C57BL/6Smoc-Cd276tm2(hB7H3)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00107

The endogenous mouse Cd276 gene was replaced by human CD276 gene.

Mice

Cd8a-IRES-DTRGFP/Cd8a-IRES-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Cd8aem2(IRES-DTREGFP)Cd8aem1(V5-IRES-luci-2A-EGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-210399

Cd8a-IRES-DTRGFP(NM-KI-190045) was crossed with Cd8a-IRES-Luc-2A-EGFP(NM-KI-18030) to generate Cd8a-IRES-DTRGFP/Cd8a-IRES-luc-2A-EGFP mice.

Mice

hCD81/hOCLN

Strain Name：C57BL/6Smoc-Cd81em1(hCD81)Oclnem1(hOCLN)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000107

These mice are obtained through breeding of two single gene humanized mice.

Mice

B2m-KO(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1SmocB2mem1Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-002

This B2m knockout mouse model was obtained by knocking out the exon 2-3 region of mouse B2m gene on the background of NMG mouse.

Mice

Ly6g-Cre-2A-tdTomato

Strain Name：C57BL/6Smoc-Ly6gem2(iCre-P2A-tdTomato-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200219

A iCre-P2A-tdTomato-polyA expression cassette was knocked into the Ly6g gene start codon site.

Mice

hCTLA-4/Cd8a-IRES-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Ctla4em1(hCTLA4)Cd8aem1(V5-IRES-luc-2A-EGFP)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210374

hCTLA4(NM-HU-00014) was crossed with Cd8a-IRES-Akaluc-2A-EGFP(NM-KI-18030) to generate hCTLA4/Cd8a-IRES-Akaluc-2A-EGFP mice.

Mice

hC5AR1/C5AR2

Strain Name：C57BL/6Smoc-C5ar1tm1(hC5AR1)C5ar2tm1(hC5AR2)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000018

The endogenous mouse C5ar1 and C5ar2 gene was replaced by human C5AR1 and hC5AR2 gene.

Mice

hCD47

Strain Name：C57BL/6Smoc-Cd47em1(hCD47)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00050

The endogenous mouse Cd47 gene was replaced by human CD47 gene.

Mice

hTIGIT

Strain Name：C57BL/6Smoc-Tigitem1(hTIGIT)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00053

The endogenous mouse Tigit gene was replaced by human TIGIT gene. While hTIGIT(3)(Stock No.NM-HU-200244) mice function similarly to hTIGIT mice,for more detailed information please contact our technical advisor.

Mice

hCCR2

Strain Name：C57BL/6Smoc-Ccr2em2(hCCR2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18026

The endogenous mouse Ccr2 gene was replaced by human CCR2 gene.

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