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Models

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Mice

A26C3-KO

Strain Name：C57BL/6Smoc-A26C3em1Smoc
Strain State：Developing | Cat. NO.：TBD
Validation Data：Absence

Exon 2 of A26C3 gene was deleted to generate A26C3 knockout mice.

Mice

hIL12RB2

Strain Name：C57BL/6Smoc-Il12rb2em(hIL12RB2)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-215019
Validation Data：Presence

The endogenous mouse Il12rb2 gene was replaced by human IL12RB2 gene.

Mice

hNR1I2

Strain Name：C57BL/6Smoc-Nr1i2em3(hNR1I2)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000066
Validation Data：Presence

The endogenous mouse Nr1i2 gene was replaced by human NR1I2 gene.

Mice

hPD-1/hCD40

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Cd40em1(hCD40)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190017
Validation Data：Absence

hPD-1(NM-HU-00015) was crossed with hCD40(NM-HU-00076) to generate hPD-1/hCD40.

Mice

hPD-L1(2)/hCD28

Strain Name：C57BL/6Smoc-Cd274em2(hPD-L1)Cd28em2(hCD28)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210370
Validation Data：Absence

hPD-L1(2)(NM-HU-190039) was crossed with hCD28(NM-HU-190011）to generate hPD-L1(2)/hCD28 mice

Mice

hOX40/hCTLA-4

Strain Name：C57BL/6Smoc-Tnfrsf4em3(hTNFRSF4)Ctla4em1(hCTLA4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00105
Validation Data：Absence

These mice are OX40 and CTLA4 double knockin mouse models which can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

Sst-IRES-Cre

Strain Name：C57BL/6Smoc-Sst1em1(IRES-Cre-Wpre-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190091
Validation Data：Presence

A IRES-Cre-Wpre-polyA expression cassette was knocked into the Sst gene stop codon site.

Mice

Pax7-IRES-CreERT2

Strain Name：C57BL/6Smoc-Pax7em1(IRES-Cre-ERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200099
Validation Data：Presence

A IRES-Cre-ERT2 expression cassette was knocked into the Pax7 gene stop codon site. Pax7 is expressed in myogenic progenitor cells. Pax7 is essential for the myogenic potential, survival, and proliferation of myogenic progenitors. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Pax7 after tamoxifen treatment.

Mice

hSERPINH1

Strain Name：C57BL/6Smoc-Serpinh1em1(hSERPINH1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-225081
Validation Data：Presence

The endogenous mouse Serpinh1 gene was replaced by human SERPINH1 gene.

Mice

1300017j02Rik-KO

Strain Name：C57BL/6Smoc-1300017j02Rikem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190231
Validation Data：Absence

This 1300017j02Rik knockout mouse model was generated by knocking out the exon2-12 region of the 1300017j02Rik.

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