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Models

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Mice

Col1a1-TRE3G-dCas9-VPR-EGFP

Strain Name：C57BL/6Smoc-Col1a1em1(TRE3G-dCas9-VPR-eGFP-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-00123
Validation Data：Absence

These mice harbor a TRE3G-dCas9-VPR(VP64-p65-Rta)-eGFP-pA tetracycline-controlled transcriptional activation cassette in mouse Col1a1 loci. This strain can be used in CRISPR mediated target gene transcriptional activation (CRISPRa).

Mice

Il12a-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il12aem1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00024
Validation Data：Absence

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il12a.

Mice

hIL2RA

Strain Name：C57BL/6Smoc-Il2raem1(hIL2RA)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190064
Validation Data：Presence

The endogenous mouse Il2ra gene was replaced by human IL2RA gene.

Mice

Abcg8-KO

Strain Name：C57BL/6Smoc-Abcg8em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200906
Validation Data：Absence

Exon 3 of Abcg8 gene was deleted to generate Abcg8 knockout mice.

Mice

hCD37

Strain Name：C57BL/6Smoc-Cd37em1(hCD37)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-225029
Validation Data：Presence

The endogenous mouse Cd37 gene was replaced by human CD37 gene.

Mice

hIL17F

Strain Name：C57BL/6Smoc-Il17fem2(hIL17F)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190007
Validation Data：Presence

The endogenous mouse Il17 gene was replaced by human IL17F gene.

Mice

hIGHG1

Strain Name：C57BL/6Smoc-Ighg1em1(hIGHG1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-225091
Validation Data：Presence

The endogenous mouse Ighg1 gene was replaced by human IGHG1 gene.

Mice

hCD3E/hCD20(2)

Strain Name：C57BL/6Smoc-Cd3eem1(hCD3E)Ms4a1em2 (hCD20)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220035
Validation Data：Absence

hCD3E(NM-HU-00114) mice were crossed with hCD20(2)(NM-HU-200114) to generate hCD3E/hCD20(2) mice.

Mice

A26c3-Flox

Strain Name：C57BL/6Smoc-A26c3em1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD
Validation Data：Absence

These mice carry loxP sites flanking target exons of A26c3 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of A26c3 gene.

Mice

Zp3-2A-Cre

Strain Name：C57BL/6Smoc-Zp3em(2A-Cre-WPRE-pA)1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-225029
Validation Data：Absence

2A-Cre-WPRE-pA expression cassette was knocked into the Zp3 gene .

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